Structural elaboration of the surprising ortho-zincation of benzyl methyl ether

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Abstract

Breaking with convention, the reaction of the sodium zincate, [(TMEDA)Na(μ-TMP)(μ-tBu)Zn(tBu)] with benzyl methyl ether (PhCH2OMe) produces exclusively an ortho-zincated intermediate [(TMEDA)Na(μ-TMP)(μ-C6H4CH2OMe)Zn(tBu)] instead of the expected 'thermodynamic' α-metallated product.
Original languageEnglish
Pages (from-to)2319-2321
Number of pages3
JournalChemical Communications (London)
Volume46
Issue number13
Early online date20 Jan 2010
DOIs
Publication statusPublished - 7 Apr 2010

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Keywords

  • ortho-zincation
  • benzyl methyl ether
  • chemistry

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