Stress analysis of carotid atheroma in a TIA patient using MRI-based fluid-structure interaction method

Hao Gao, Quan Long, Umar Sadat, Martin Graves, Jonathan Gillard, Zhiyong Li

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Rupture of atherosclerotic plaque is a major cause of mortality. Plaque stress analysis, based on patient-specific multisequence in vivo MRI, can provide critical information for the understanding of plaque rupture and could eventually lead to plaque rupture prediction. However, the direct link between stress and plaque rupture is not fully understood. In the present study, the plaque from a patient who recently experienced a transient ischaemic attack (TIA) was studied using a fluid–structure interaction method to quantify stress distribution in the plaque region based on in vivo MR images. The results showed that wall shear stress is generally low in the artery with a slight increase at the plaque throat owing to minor luminal narrowing. The oscillatory shear index is much higher in the proximal part of the plaque. Both local wall stress concentrations and the relative stress variation distribution during a cardiac cycle indicate that the actual plaque rupture site is collocated with the highest rupture risk region in the studied patient.
LanguageEnglish
Pages46-54
Number of pages9
JournalBritish Journal of Radiology
Volume82
Issue numbers46-s54
DOIs
Publication statusPublished - 2009

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Transient Ischemic Attack
Atherosclerotic Plaques
Rupture
Pharynx
Arteries
Mortality

Keywords

  • carotid atheroma
  • mri
  • stress analysis

Cite this

Gao, Hao ; Long, Quan ; Sadat, Umar ; Graves, Martin ; Gillard, Jonathan ; Li, Zhiyong. / Stress analysis of carotid atheroma in a TIA patient using MRI-based fluid-structure interaction method. In: British Journal of Radiology. 2009 ; Vol. 82, No. s46-s54. pp. 46-54.
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Stress analysis of carotid atheroma in a TIA patient using MRI-based fluid-structure interaction method. / Gao, Hao; Long, Quan; Sadat, Umar; Graves, Martin; Gillard, Jonathan; Li, Zhiyong.

In: British Journal of Radiology, Vol. 82, No. s46-s54, 2009, p. 46-54.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Stress analysis of carotid atheroma in a TIA patient using MRI-based fluid-structure interaction method

AU - Gao, Hao

AU - Long, Quan

AU - Sadat, Umar

AU - Graves, Martin

AU - Gillard, Jonathan

AU - Li, Zhiyong

PY - 2009

Y1 - 2009

N2 - Rupture of atherosclerotic plaque is a major cause of mortality. Plaque stress analysis, based on patient-specific multisequence in vivo MRI, can provide critical information for the understanding of plaque rupture and could eventually lead to plaque rupture prediction. However, the direct link between stress and plaque rupture is not fully understood. In the present study, the plaque from a patient who recently experienced a transient ischaemic attack (TIA) was studied using a fluid–structure interaction method to quantify stress distribution in the plaque region based on in vivo MR images. The results showed that wall shear stress is generally low in the artery with a slight increase at the plaque throat owing to minor luminal narrowing. The oscillatory shear index is much higher in the proximal part of the plaque. Both local wall stress concentrations and the relative stress variation distribution during a cardiac cycle indicate that the actual plaque rupture site is collocated with the highest rupture risk region in the studied patient.

AB - Rupture of atherosclerotic plaque is a major cause of mortality. Plaque stress analysis, based on patient-specific multisequence in vivo MRI, can provide critical information for the understanding of plaque rupture and could eventually lead to plaque rupture prediction. However, the direct link between stress and plaque rupture is not fully understood. In the present study, the plaque from a patient who recently experienced a transient ischaemic attack (TIA) was studied using a fluid–structure interaction method to quantify stress distribution in the plaque region based on in vivo MR images. The results showed that wall shear stress is generally low in the artery with a slight increase at the plaque throat owing to minor luminal narrowing. The oscillatory shear index is much higher in the proximal part of the plaque. Both local wall stress concentrations and the relative stress variation distribution during a cardiac cycle indicate that the actual plaque rupture site is collocated with the highest rupture risk region in the studied patient.

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KW - mri

KW - stress analysis

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