Abstract
Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β‐cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ‐induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition.
| Original language | English |
|---|---|
| Article number | e78 |
| Number of pages | 21 |
| Journal | Current Protocols |
| Volume | 1 |
| Early online date | 27 Apr 2021 |
| DOIs | |
| Publication status | Published - 27 Apr 2021 |
Keywords
- high-fat
- hyperglycemia
- insulin deficiency
- insulin resistance
- insulitis
- mouse or rat
- nicotinamide
- streptozotocin
- type 1 diabetes mellitus
- type 2 diabetes mellitus