Streptozotocin-induced diabetic models in mice and rats

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Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β‐cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ‐induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition.
Original languageEnglish
Article numbere78
Number of pages21
JournalCurrent Protocols
Early online date27 Apr 2021
Publication statusPublished - 27 Apr 2021


  • high-fat
  • hyperglycemia
  • insulin deficiency
  • insulin resistance
  • insulitis
  • mouse or rat
  • nicotinamide
  • streptozotocin
  • type 1 diabetes mellitus
  • type 2 diabetes mellitus


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