Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism

L. Zhang, J.R. Parratt, G.H. Beastall, N.J. Pyne, B.L. Furman

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33 Citations (Scopus)

Abstract

We examined the contribution of hypothyroidism to streptozotocin diabetes-induced alterations in the arrhythmia susceptibility of ex vivo hearts to regional zero-flow ischaemia. Diabetic rats received either protamine zinc insulin (10 IU/kg/day, s.c.) or triiodothyronine (10 microg/kg/day, s.c.) for 8 weeks commencing 72 h after injection of streptozotocin (60 mg/kg, i.p.). Arrhythmias were determined in ex vivo Langendorff-perfused hearts, subjected to a 30-min main left coronary artery occlusion, followed by 30-min reperfusion. Serum free thyroxine concentrations, rectal temperature and ex vivo heart rate were significantly decreased in the 8-week diabetic group.
Original languageEnglish
Pages (from-to)269-276
Number of pages8
JournalEuropean Journal of Pharmacology
Volume435
Issue number2-3
DOIs
Publication statusPublished - 2002

Keywords

  • diabetes mellitus
  • insulin
  • triiodothyronine
  • hypothyroidism
  • ventricular fibrillation
  • body weight
  • blood glucose

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