Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism

L. Zhang; J.R. Parratt; G.H. Beastall; N.J. Pyne; B.L. Furman

doi:10.1016/S0014-2999(01)01398-X

Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism

L. Zhang, J.R. Parratt, G.H. Beastall, N.J. Pyne, B.L. Furman

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

We examined the contribution of hypothyroidism to streptozotocin diabetes-induced alterations in the arrhythmia susceptibility of ex vivo hearts to regional zero-flow ischaemia. Diabetic rats received either protamine zinc insulin (10 IU/kg/day, s.c.) or triiodothyronine (10 microg/kg/day, s.c.) for 8 weeks commencing 72 h after injection of streptozotocin (60 mg/kg, i.p.). Arrhythmias were determined in ex vivo Langendorff-perfused hearts, subjected to a 30-min main left coronary artery occlusion, followed by 30-min reperfusion. Serum free thyroxine concentrations, rectal temperature and ex vivo heart rate were significantly decreased in the 8-week diabetic group.

Original language	English
Pages (from-to)	269-276
Number of pages	8
Journal	European Journal of Pharmacology
Volume	435
Issue number	2-3
DOIs	https://doi.org/10.1016/S0014-2999(01)01398-X
Publication status	Published - 2002

Keywords

diabetes mellitus
insulin
triiodothyronine
hypothyroidism
ventricular fibrillation
body weight
blood glucose

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0014-2999(01)01398-X

Cite this

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title = "Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism",

abstract = "We examined the contribution of hypothyroidism to streptozotocin diabetes-induced alterations in the arrhythmia susceptibility of ex vivo hearts to regional zero-flow ischaemia. Diabetic rats received either protamine zinc insulin (10 IU/kg/day, s.c.) or triiodothyronine (10 microg/kg/day, s.c.) for 8 weeks commencing 72 h after injection of streptozotocin (60 mg/kg, i.p.). Arrhythmias were determined in ex vivo Langendorff-perfused hearts, subjected to a 30-min main left coronary artery occlusion, followed by 30-min reperfusion. Serum free thyroxine concentrations, rectal temperature and ex vivo heart rate were significantly decreased in the 8-week diabetic group.",

keywords = "diabetes mellitus , insulin, triiodothyronine, hypothyroidism, ventricular fibrillation, body weight, blood glucose",

author = "L. Zhang and J.R. Parratt and G.H. Beastall and N.J. Pyne and B.L. Furman",

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T1 - Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism

AU - Zhang, L.

AU - Parratt, J.R.

AU - Beastall, G.H.

AU - Pyne, N.J.

AU - Furman, B.L.

PY - 2002

Y1 - 2002

N2 - We examined the contribution of hypothyroidism to streptozotocin diabetes-induced alterations in the arrhythmia susceptibility of ex vivo hearts to regional zero-flow ischaemia. Diabetic rats received either protamine zinc insulin (10 IU/kg/day, s.c.) or triiodothyronine (10 microg/kg/day, s.c.) for 8 weeks commencing 72 h after injection of streptozotocin (60 mg/kg, i.p.). Arrhythmias were determined in ex vivo Langendorff-perfused hearts, subjected to a 30-min main left coronary artery occlusion, followed by 30-min reperfusion. Serum free thyroxine concentrations, rectal temperature and ex vivo heart rate were significantly decreased in the 8-week diabetic group.

AB - We examined the contribution of hypothyroidism to streptozotocin diabetes-induced alterations in the arrhythmia susceptibility of ex vivo hearts to regional zero-flow ischaemia. Diabetic rats received either protamine zinc insulin (10 IU/kg/day, s.c.) or triiodothyronine (10 microg/kg/day, s.c.) for 8 weeks commencing 72 h after injection of streptozotocin (60 mg/kg, i.p.). Arrhythmias were determined in ex vivo Langendorff-perfused hearts, subjected to a 30-min main left coronary artery occlusion, followed by 30-min reperfusion. Serum free thyroxine concentrations, rectal temperature and ex vivo heart rate were significantly decreased in the 8-week diabetic group.

KW - diabetes mellitus

KW - insulin

KW - triiodothyronine

KW - hypothyroidism

KW - ventricular fibrillation

KW - body weight

KW - blood glucose

U2 - 10.1016/S0014-2999(01)01398-X

DO - 10.1016/S0014-2999(01)01398-X

M3 - Article

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VL - 435

SP - 269

EP - 276

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2-3

ER -

Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism

Abstract

Keywords

UN SDGs

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