We examined the contribution of hypothyroidism to streptozotocin diabetes-induced alterations in the arrhythmia susceptibility of ex vivo hearts to regional zero-flow ischaemia. Diabetic rats received either protamine zinc insulin (10 IU/kg/day, s.c.) or triiodothyronine (10 microg/kg/day, s.c.) for 8 weeks commencing 72 h after injection of streptozotocin (60 mg/kg, i.p.). Arrhythmias were determined in ex vivo Langendorff-perfused hearts, subjected to a 30-min main left coronary artery occlusion, followed by 30-min reperfusion. Serum free thyroxine concentrations, rectal temperature and ex vivo heart rate were significantly decreased in the 8-week diabetic group.
- diabetes mellitus
- ventricular fibrillation
- body weight
- blood glucose
Zhang, L., Parratt, J. R., Beastall, G. H., Pyne, N. J., & Furman, B. L. (2002). Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism. European Journal of Pharmacology, 435(2-3), 269-276. https://doi.org/10.1016/S0014-2999(01)01398-X