Strategy and tactics for hERG optimizations

Craig Jamieson, Elizabeth M. Moir, Zoran Rankovic, Grant. Wishart

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A review on the approaches used to circumvent activity at human ether-a-go-go related gene (hERG), identified through an extensive survey of the medicinal chem. literature until the end of 2006. [on SciFinder(R)]
LanguageEnglish
Title of host publicationAntitargets
Subtitle of host publicationPrediction and Prevention of Drug Side Effects
EditorsRoy J. Vaz, Thomas Klabunde
Place of PublicationWeinheim, Germany
Pages423-455
Number of pages33
Volume38
DOIs
Publication statusPublished - Jan 2008

Publication series

NameMethods and Principles in Medicinal Chemistry
PublisherWiley

Fingerprint

ethers
genes

Keywords

  • antitargets
  • case studies
  • drug optimization
  • hERG optimizations
  • strategies to diminish hERG
  • structural modifications
  • formation of zwitterions
  • control of log P
  • attenuation of pKa

Cite this

Jamieson, C., Moir, E. M., Rankovic, Z., & Wishart, G. (2008). Strategy and tactics for hERG optimizations. In R. J. Vaz, & T. Klabunde (Eds.), Antitargets: Prediction and Prevention of Drug Side Effects (Vol. 38, pp. 423-455). (Methods and Principles in Medicinal Chemistry). Weinheim, Germany. https://doi.org/10.1002/9783527621460.ch18
Jamieson, Craig ; Moir, Elizabeth M. ; Rankovic, Zoran ; Wishart, Grant. / Strategy and tactics for hERG optimizations. Antitargets: Prediction and Prevention of Drug Side Effects. editor / Roy J. Vaz ; Thomas Klabunde. Vol. 38 Weinheim, Germany, 2008. pp. 423-455 (Methods and Principles in Medicinal Chemistry).
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Jamieson, C, Moir, EM, Rankovic, Z & Wishart, G 2008, Strategy and tactics for hERG optimizations. in RJ Vaz & T Klabunde (eds), Antitargets: Prediction and Prevention of Drug Side Effects. vol. 38, Methods and Principles in Medicinal Chemistry, Weinheim, Germany, pp. 423-455. https://doi.org/10.1002/9783527621460.ch18

Strategy and tactics for hERG optimizations. / Jamieson, Craig; Moir, Elizabeth M.; Rankovic, Zoran; Wishart, Grant.

Antitargets: Prediction and Prevention of Drug Side Effects. ed. / Roy J. Vaz; Thomas Klabunde. Vol. 38 Weinheim, Germany, 2008. p. 423-455 (Methods and Principles in Medicinal Chemistry).

Research output: Chapter in Book/Report/Conference proceedingChapter

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KW - case studies

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KW - strategies to diminish hERG

KW - structural modifications

KW - formation of zwitterions

KW - control of log P

KW - attenuation of pKa

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Jamieson C, Moir EM, Rankovic Z, Wishart G. Strategy and tactics for hERG optimizations. In Vaz RJ, Klabunde T, editors, Antitargets: Prediction and Prevention of Drug Side Effects. Vol. 38. Weinheim, Germany. 2008. p. 423-455. (Methods and Principles in Medicinal Chemistry). https://doi.org/10.1002/9783527621460.ch18