Strategy and tactics for hERG optimizations

Craig Jamieson, Elizabeth M. Moir, Zoran Rankovic, Grant. Wishart

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A review on the approaches used to circumvent activity at human ether-a-go-go related gene (hERG), identified through an extensive survey of the medicinal chem. literature until the end of 2006. [on SciFinder(R)]
Original languageEnglish
Title of host publicationAntitargets
Subtitle of host publicationPrediction and Prevention of Drug Side Effects
EditorsRoy J. Vaz, Thomas Klabunde
Place of PublicationWeinheim, Germany
Pages423-455
Number of pages33
Volume38
DOIs
Publication statusPublished - Jan 2008

Publication series

NameMethods and Principles in Medicinal Chemistry
PublisherWiley

Keywords

  • antitargets
  • case studies
  • drug optimization
  • hERG optimizations
  • strategies to diminish hERG
  • structural modifications
  • formation of zwitterions
  • control of log P
  • attenuation of pKa

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  • Cite this

    Jamieson, C., Moir, E. M., Rankovic, Z., & Wishart, G. (2008). Strategy and tactics for hERG optimizations. In R. J. Vaz, & T. Klabunde (Eds.), Antitargets: Prediction and Prevention of Drug Side Effects (Vol. 38, pp. 423-455). (Methods and Principles in Medicinal Chemistry). Weinheim, Germany. https://doi.org/10.1002/9783527621460.ch18