TY - JOUR
T1 - Strategies for discovering drugs from previously unexplored natural products
AU - Harvey, Alan
PY - 2000/7/1
Y1 - 2000/7/1
N2 - Natural products are the most consistently successful source of drug leads. Despite this, their use in drug discovery has fallen out of favour. Natural products continue to provide greater structural diversity than standard combinatorial chemistry and so they offer major opportunities for finding novel low molecular weight lead structures that are active against a wide range of assay targets. As less than 10% of the world's biodiversity has been tested for biological activity, many more useful natural lead compounds are awaiting discovery. The challenge is how to access this natural chemical diversity. Copyright (C) 2000 Elsevier Science Ltd.
AB - Natural products are the most consistently successful source of drug leads. Despite this, their use in drug discovery has fallen out of favour. Natural products continue to provide greater structural diversity than standard combinatorial chemistry and so they offer major opportunities for finding novel low molecular weight lead structures that are active against a wide range of assay targets. As less than 10% of the world's biodiversity has been tested for biological activity, many more useful natural lead compounds are awaiting discovery. The challenge is how to access this natural chemical diversity. Copyright (C) 2000 Elsevier Science Ltd.
KW - biodiversity
KW - natural products
KW - high throughput screening
KW - combinatorial genetics
KW - plant tissue culture
KW - drug discovery
UR - http://www.scopus.com/inward/record.url?scp=0034237675&partnerID=8YFLogxK
UR - https://www.sciencedirect.com/journal/drug-discovery-today
U2 - 10.1016/S1359-6446(00)01511-7
DO - 10.1016/S1359-6446(00)01511-7
M3 - Review article
AN - SCOPUS:0034237675
SN - 1359-6446
VL - 5
SP - 294
EP - 300
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 7
ER -