Storage and recall in the CA1 microcircuit of the hippocampus: a biophysical model

Vassilis Cutsuridis, Russell Hunter, Stuart Cobb, Bruce Graham

Research output: Contribution to conferenceAbstract

Abstract

It has been suggested that the hippocampal theta rhythm can contribute to memory formation by separating encoding and retrieval of memories into different functional cycles [1]. Herein, we investigate via computer simulations the mechanisms by which storage of spatio-temporal input patterns is achieved by the CA1 microcircuitry. A model of the CA1 microcircuitry is presented using biophysical representations of its major cell types including pyramidal cells and three types of inhibitory interneurons: basket cells, chandelier cells and bistratified cells. Inputs to the network come from the medial septum, entorhinal cortex and CA3 Schaffer collaterals. Patterns of CA3 input are stored via an STDP-type learning rule on the pyramidal cell target synapses. The other inputs provide context and timing information. The model simulates accurately the timing of firing of different hippocampal cell types relative to the theta rhythm and proposes functional roles for the different classes of inhibitory interneurons in the storage and recall of input patterns.

Conference

ConferenceSixteenth Annual Computational Neuroscience Meeting: CNS*2007
Abbreviated titleCNS*2007
CountryCanada
CityToronto
Period7/07/0712/07/07
Internet address

Fingerprint

Hippocampus
Theta Rhythm
Pyramidal Cells
Interneurons
Entorhinal Cortex
Computer Simulation
Synapses
Learning

Keywords

  • microcircuit
  • hippocampus
  • pyramidal cell
  • onput pattern
  • inhibitory interneuron
  • Theta rhythm
  • medial septum
  • biophysical model

Cite this

Cutsuridis, V., Hunter, R., Cobb, S., & Graham, B. (2007). Storage and recall in the CA1 microcircuit of the hippocampus: a biophysical model. 33. Abstract from Sixteenth Annual Computational Neuroscience Meeting: CNS*2007, Toronto, Canada. https://doi.org/10.1186/1471-2202-8-S2-P33
Cutsuridis, Vassilis ; Hunter, Russell ; Cobb, Stuart ; Graham, Bruce. / Storage and recall in the CA1 microcircuit of the hippocampus : a biophysical model. Abstract from Sixteenth Annual Computational Neuroscience Meeting: CNS*2007, Toronto, Canada.1 p.
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Cutsuridis, V, Hunter, R, Cobb, S & Graham, B 2007, 'Storage and recall in the CA1 microcircuit of the hippocampus: a biophysical model' Sixteenth Annual Computational Neuroscience Meeting: CNS*2007, Toronto, Canada, 7/07/07 - 12/07/07, pp. 33. https://doi.org/10.1186/1471-2202-8-S2-P33

Storage and recall in the CA1 microcircuit of the hippocampus : a biophysical model. / Cutsuridis, Vassilis; Hunter, Russell; Cobb, Stuart; Graham, Bruce.

2007. 33 Abstract from Sixteenth Annual Computational Neuroscience Meeting: CNS*2007, Toronto, Canada.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Storage and recall in the CA1 microcircuit of the hippocampus

T2 - a biophysical model

AU - Cutsuridis, Vassilis

AU - Hunter, Russell

AU - Cobb, Stuart

AU - Graham, Bruce

PY - 2007/7/6

Y1 - 2007/7/6

N2 - It has been suggested that the hippocampal theta rhythm can contribute to memory formation by separating encoding and retrieval of memories into different functional cycles [1]. Herein, we investigate via computer simulations the mechanisms by which storage of spatio-temporal input patterns is achieved by the CA1 microcircuitry. A model of the CA1 microcircuitry is presented using biophysical representations of its major cell types including pyramidal cells and three types of inhibitory interneurons: basket cells, chandelier cells and bistratified cells. Inputs to the network come from the medial septum, entorhinal cortex and CA3 Schaffer collaterals. Patterns of CA3 input are stored via an STDP-type learning rule on the pyramidal cell target synapses. The other inputs provide context and timing information. The model simulates accurately the timing of firing of different hippocampal cell types relative to the theta rhythm and proposes functional roles for the different classes of inhibitory interneurons in the storage and recall of input patterns.

AB - It has been suggested that the hippocampal theta rhythm can contribute to memory formation by separating encoding and retrieval of memories into different functional cycles [1]. Herein, we investigate via computer simulations the mechanisms by which storage of spatio-temporal input patterns is achieved by the CA1 microcircuitry. A model of the CA1 microcircuitry is presented using biophysical representations of its major cell types including pyramidal cells and three types of inhibitory interneurons: basket cells, chandelier cells and bistratified cells. Inputs to the network come from the medial septum, entorhinal cortex and CA3 Schaffer collaterals. Patterns of CA3 input are stored via an STDP-type learning rule on the pyramidal cell target synapses. The other inputs provide context and timing information. The model simulates accurately the timing of firing of different hippocampal cell types relative to the theta rhythm and proposes functional roles for the different classes of inhibitory interneurons in the storage and recall of input patterns.

KW - microcircuit

KW - hippocampus

KW - pyramidal cell

KW - onput pattern

KW - inhibitory interneuron

KW - Theta rhythm

KW - medial septum

KW - biophysical model

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DO - 10.1186/1471-2202-8-S2-P33

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Cutsuridis V, Hunter R, Cobb S, Graham B. Storage and recall in the CA1 microcircuit of the hippocampus: a biophysical model. 2007. Abstract from Sixteenth Annual Computational Neuroscience Meeting: CNS*2007, Toronto, Canada. https://doi.org/10.1186/1471-2202-8-S2-P33