Abstract
A convergent and stereoselective synthesis of chiral cyclopentyl- and cyclohexylamine derivatives of nucleoside Q precursor (PreQ0) has been accomplished. This synthetic route allows for an efficient preparation of 4-substituted analogues with interesting three-dimensional character, including chiral cyclopentane-1,2-diol and -1,2,3-triol derivatives. This unusual substitution pattern provides a useful starting point for the discovery of novel bioactive molecules.
Original language | English |
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Pages (from-to) | 1333-1338 |
Number of pages | 6 |
Journal | Beilstein Journal of Organic Chemistry |
Volume | 10 |
DOIs | |
Publication status | Published - 11 Jun 2014 |
Keywords
- diol synthesis
- nucleosides
- stereoselective amine synthesis
- triol synthesis