Stereoselective remote functionalization via palladium catalyzed redox-relay Heck methodologies

Holly E. Bonfield, Damien Valette, David M. Lindsay, Marc Reid

Research output: Contribution to journalArticlepeer-review

1 Downloads (Pure)

Abstract

Exploration of novel, three-dimensional chemical space is of growing interest in the drug discovery community and with this comes the challenge for synthetic chemists to devise new stereoselective methods to introduce chirality in a rapid and efficient manner. This Minireview provides a timely summary of the development of palladium-catalyzed asymmetric redox-relay Heck-type processes. These reactions represent an important class of transformation for the selective introduction of remote stereocenters, and have risen to prominence over the past decade. Within this Minireview, the vast scope of these transformations will be showcased, alongside applications to pharmaceutically relevant chiral building blocks and drug substances. To complement this overview, a mechanistic summary and discussion of the current limitations of the transformation are presented, followed by an outlook on future areas of investigation.

Original languageEnglish
Pages (from-to)158-174
Number of pages17
JournalChemistry - A European Journal
Volume27
Issue number1
Early online date3 Aug 2020
DOIs
Publication statusPublished - 4 Jan 2021

Keywords

  • asymmetric catalysis
  • chain walking
  • Heck reaction
  • palladium
  • relay

Fingerprint Dive into the research topics of 'Stereoselective remote functionalization via palladium catalyzed redox-relay Heck methodologies'. Together they form a unique fingerprint.

Cite this