Projects per year
Exploration of novel, three-dimensional chemical space is of growing interest in the drug discovery community and with this comes the challenge for synthetic chemists to devise new stereoselective methods to introduce chirality in a rapid and efficient manner. This Minireview provides a timely summary of the development of palladium-catalyzed asymmetric redox-relay Heck-type processes. These reactions represent an important class of transformation for the selective introduction of remote stereocenters, and have risen to prominence over the past decade. Within this Minireview, the vast scope of these transformations will be showcased, alongside applications to pharmaceutically relevant chiral building blocks and drug substances. To complement this overview, a mechanistic summary and discussion of the current limitations of the transformation are presented, followed by an outlook on future areas of investigation.
|Number of pages||17|
|Journal||Chemistry - A European Journal|
|Early online date||3 Aug 2020|
|Publication status||Published - 4 Jan 2021|
- asymmetric catalysis
- chain walking
- Heck reaction
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Manganese by Numbers: A ‘Chem-Tech’ Toolbox for Innovation (Leverhulme)
Leverhulme Trust, Glaxo Smithkline (UK)
1/01/17 → 31/12/19
Project: Research Fellowship