Abstract
In recent years, terahertz in-line sensing has been used to monitor the film coating thickness of individual pharmaceutical tablets during the coating process. In the previous work, the in-line measurements were verified against off-line measurements of samples from the same population. Here, we report on our recent progress to further verify the validity of the terahertz in-line measurement modality using discrete element modelling for an artificial lab-scale tablet mixing process inside a tablet pan coater. By coupling discrete modelling with a ray-tracing method, it is then possible to estimate the cumulative measurements taken, which in turn can guide towards the fine-tuning of the selection criteria as part of measurement analysis.
| Original language | English |
|---|---|
| Pages (from-to) | 1775-1779 |
| Number of pages | 5 |
| Journal | IET Microwaves, Antennas and Propagation |
| Volume | 12 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 12 Sept 2018 |
Funding
The authors would like to acknowledge the financial support from UK EPSRC Research grant nos. EP/L019787/1 and EP/L019922/1. HL also acknowledges support from EP/R019460/1 and the Joy Welch Educational Charitable Trust.
Keywords
- optical coherence tomography
- OCT
- pharmaceutical film coatings
- tablet mixing
- tablet coating
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