Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling

Hungyen Lin, Chunlei Pei, Daniel Markl, Yaochun Shen, James A. Elliott, J. Axel Zeitler

Research output: Contribution to journalArticle

2 Citations (Scopus)
6 Downloads (Pure)

Abstract

In recent years, terahertz in-line sensing has been used to monitor the film coating thickness of individual pharmaceutical tablets during the coating process. In the previous work, the in-line measurements were verified against off-line measurements of samples from the same population. Here, we report on our recent progress to further verify the validity of the terahertz in-line measurement modality using discrete element modelling for an artificial lab-scale tablet mixing process inside a tablet pan coater. By coupling discrete modelling with a ray-tracing method, it is then possible to estimate the cumulative measurements taken, which in turn can guide towards the fine-tuning of the selection criteria as part of measurement analysis.

Original languageEnglish
Pages (from-to)1775-1779
Number of pages5
JournalIET Microwaves, Antennas and Propagation
Volume12
Issue number11
DOIs
Publication statusPublished - 12 Sep 2018

Keywords

  • optical coherence tomography
  • OCT
  • pharmaceutical film coatings
  • tablet mixing
  • tablet coating

Fingerprint Dive into the research topics of 'Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling'. Together they form a unique fingerprint.

Cite this