Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling

Hungyen Lin, Chunlei Pei, Daniel Markl, Yaochun Shen, James A. Elliott, J. Axel Zeitler

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In recent years, terahertz in-line sensing has been used to monitor the film coating thickness of individual pharmaceutical tablets during the coating process. In the previous work, the in-line measurements were verified against off-line measurements of samples from the same population. Here, we report on our recent progress to further verify the validity of the terahertz in-line measurement modality using discrete element modelling for an artificial lab-scale tablet mixing process inside a tablet pan coater. By coupling discrete modelling with a ray-tracing method, it is then possible to estimate the cumulative measurements taken, which in turn can guide towards the fine-tuning of the selection criteria as part of measurement analysis.

LanguageEnglish
Pages1775-1779
Number of pages5
JournalIET Microwaves, Antennas and Propagation
Volume12
Issue number11
DOIs
Publication statusPublished - 12 Sep 2018

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Coatings
Ray tracing
Drug products
Tuning

Keywords

  • optical coherence tomography
  • OCT
  • pharmaceutical film coatings
  • tablet mixing
  • tablet coating

Cite this

Lin, Hungyen ; Pei, Chunlei ; Markl, Daniel ; Shen, Yaochun ; Elliott, James A. ; Axel Zeitler, J. / Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling. In: IET Microwaves, Antennas and Propagation. 2018 ; Vol. 12, No. 11. pp. 1775-1779.
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Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling. / Lin, Hungyen; Pei, Chunlei; Markl, Daniel; Shen, Yaochun; Elliott, James A.; Axel Zeitler, J.

In: IET Microwaves, Antennas and Propagation, Vol. 12, No. 11, 12.09.2018, p. 1775-1779.

Research output: Contribution to journalArticle

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