Stem cell implants for cancer therapy: TRAIL-expressing mesenchymal stem cells target cancer cells in situ

Michaela R Reagan; F Philipp Seib; Douglas W McMillin; Elizabeth K Sage; Constantine S Mitsiades; Sam M Janes; Irene M Ghobrial; David L Kaplan

doi:10.4048/jbc.2012.15.3.273

Stem cell implants for cancer therapy: TRAIL-expressing mesenchymal stem cells target cancer cells in situ

Michaela R Reagan, F Philipp Seib, Douglas W McMillin, Elizabeth K Sage, Constantine S Mitsiades, Sam M Janes, Irene M Ghobrial, David L Kaplan

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Tumor-specific delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), an apoptosis-inducing peptide, at effective doses remains challenging. Herein we demonstrate the utility of a scaffold-based delivery system for sustained therapeutic cell release that capitalizes on the tumor-homing properties of mesenchymal stem cells (MSCs) and their ability to express genetically-introduced therapeutic genes.

Original language	English
Pages (from-to)	273-282
Number of pages	10
Journal	Journal of breast cancer
Volume	15
Issue number	3
DOIs	https://doi.org/10.4048/jbc.2012.15.3.273
Publication status	Published - Sep 2012

Keywords

breast neoplasms
mesenchymal stem cells
tissue engineering
tissue therapy
TNF-related apoptosis-inducing ligand

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.4048/jbc.2012.15.3.273

Cite this

@article{15051e261d9543e181bf8c71bf69b0be,

title = "Stem cell implants for cancer therapy: TRAIL-expressing mesenchymal stem cells target cancer cells in situ",

abstract = "Tumor-specific delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), an apoptosis-inducing peptide, at effective doses remains challenging. Herein we demonstrate the utility of a scaffold-based delivery system for sustained therapeutic cell release that capitalizes on the tumor-homing properties of mesenchymal stem cells (MSCs) and their ability to express genetically-introduced therapeutic genes.",

keywords = "breast neoplasms, mesenchymal stem cells, tissue engineering, tissue therapy, TNF-related apoptosis-inducing ligand",

author = "Reagan, {Michaela R} and Seib, {F Philipp} and McMillin, {Douglas W} and Sage, {Elizabeth K} and Mitsiades, {Constantine S} and Janes, {Sam M} and Ghobrial, {Irene M} and Kaplan, {David L}",

year = "2012",

month = sep,

doi = "10.4048/jbc.2012.15.3.273",

language = "English",

volume = "15",

pages = "273--282",

journal = "Journal of breast cancer",

issn = "1738-6756",

publisher = "Korean Breast Cancer Society",

number = "3",

}

TY - JOUR

T1 - Stem cell implants for cancer therapy

T2 - TRAIL-expressing mesenchymal stem cells target cancer cells in situ

AU - Reagan, Michaela R

AU - Seib, F Philipp

AU - McMillin, Douglas W

AU - Sage, Elizabeth K

AU - Mitsiades, Constantine S

AU - Janes, Sam M

AU - Ghobrial, Irene M

AU - Kaplan, David L

PY - 2012/9

Y1 - 2012/9

N2 - Tumor-specific delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), an apoptosis-inducing peptide, at effective doses remains challenging. Herein we demonstrate the utility of a scaffold-based delivery system for sustained therapeutic cell release that capitalizes on the tumor-homing properties of mesenchymal stem cells (MSCs) and their ability to express genetically-introduced therapeutic genes.

AB - Tumor-specific delivery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), an apoptosis-inducing peptide, at effective doses remains challenging. Herein we demonstrate the utility of a scaffold-based delivery system for sustained therapeutic cell release that capitalizes on the tumor-homing properties of mesenchymal stem cells (MSCs) and their ability to express genetically-introduced therapeutic genes.

KW - breast neoplasms

KW - mesenchymal stem cells

KW - tissue engineering

KW - tissue therapy

KW - TNF-related apoptosis-inducing ligand

U2 - 10.4048/jbc.2012.15.3.273

DO - 10.4048/jbc.2012.15.3.273

M3 - Article

C2 - 23091539

VL - 15

SP - 273

EP - 282

JO - Journal of breast cancer

JF - Journal of breast cancer

SN - 1738-6756

IS - 3

ER -

Stem cell implants for cancer therapy: TRAIL-expressing mesenchymal stem cells target cancer cells in situ

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this