Statin use in Brazil: findings and implications

R. C. R. M. Nascimento, A. A. Guerra Júnior, J. Alvares, I. C. Gomes, B. Godman, M. Bennie, A. B. Kurdi, F. A. de Acurcio

Research output: Contribution to journalArticle

Abstract

Introduction and objectives: Stains have become an integral part of treatment to reduce cardiac events in patients with cardiovascular disease. However, their use within the public healthcare system in Brazil is unknown. Consequently, we sought to determine and characterize statin use in primary healthcare delivered by the public health system (SUS) in Brazil and evaluate associated patient factors to improve future use. Methods: Cross-sectional study with a national representative sample from five Brazilian regions, derived from the National Survey on Access, Use and Promotion of Rational Use of Medicines using a multi-stage complex sampling plan. Patients over 18 years old were interviewed from July/2014 to May/2015. Prevalence of statin use and statins’ self-reported adherence were determined amongst medicine users. The association between statin use and sociodemographic/health condition variables were assessed using logistic regression. Results: 8,803 patients were interviewed; of which, 6,511 were medicines users. The prevalence of statins use was 9.4% with simvastatin (90.3%), atorvastatin (4.7%) and rosuvastatin (1.9%) the most used statins. Poor adherence was described by 6.5% of patients. Statins use was significantly associated with age ≥65 years old, higher educational level, residence in the South, metabolic and heart diseases, alcohol consumption and polypharmacy. Conclusions: This is the first population based study in Brazil to assess statin use in SUS primary healthcare patients. Addressing inequalities in access and use of medicines including statins is an important step in achieving the full benefit of statins in Brazil, with the findings guiding future research and policies.
LanguageEnglish
Pages1809-1817
Number of pages9
JournalCurrent Medical Research and Opinion
Volume43
Issue number10
Early online date12 Mar 2018
DOIs
StatePublished - 12 Apr 2018

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Brazil
Primary Health Care
Polypharmacy
Simvastatin
Metabolic Diseases
Alcohol Drinking
Heart Diseases
Coloring Agents
Cardiovascular Diseases
Public Health
Cross-Sectional Studies
Logistic Models
Medicine
Delivery of Health Care

Keywords

  • cardiovascular diseases
  • hypercholesterolemia
  • statins
  • primary health care
  • drug utilisation
  • Brazil

Cite this

Nascimento, R. C. R. M., Guerra Júnior, A. A., Alvares, J., Gomes, I. C., Godman, B., Bennie, M., ... Acurcio, F. A. D. (2018). Statin use in Brazil: findings and implications. Current Medical Research and Opinion, 43(10), 1809-1817. DOI: 10.1080/03007995.2018.1451312
Nascimento, R. C. R. M. ; Guerra Júnior, A. A. ; Alvares, J. ; Gomes, I. C. ; Godman, B. ; Bennie, M. ; Kurdi, A. B. ; Acurcio, F. A. de. / Statin use in Brazil : findings and implications. In: Current Medical Research and Opinion. 2018 ; Vol. 43, No. 10. pp. 1809-1817
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Nascimento, RCRM, Guerra Júnior, AA, Alvares, J, Gomes, IC, Godman, B, Bennie, M, Kurdi, AB & Acurcio, FAD 2018, 'Statin use in Brazil: findings and implications' Current Medical Research and Opinion, vol. 43, no. 10, pp. 1809-1817. DOI: 10.1080/03007995.2018.1451312

Statin use in Brazil : findings and implications. / Nascimento, R. C. R. M.; Guerra Júnior, A. A.; Alvares, J.; Gomes, I. C.; Godman, B.; Bennie, M.; Kurdi, A. B.; Acurcio, F. A. de.

In: Current Medical Research and Opinion, Vol. 43, No. 10, 12.04.2018, p. 1809-1817.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Statin use in Brazil

T2 - Current Medical Research and Opinion

AU - Nascimento,R. C. R. M.

AU - Guerra Júnior,A. A.

AU - Alvares,J.

AU - Gomes,I. C.

AU - Godman,B.

AU - Bennie,M.

AU - Kurdi,A. B.

AU - Acurcio,F. A. de

N1 - This is an Accepted Manuscript of an article published by Taylor & Francis in Current Medical Research and Opinion on 10/03/2018, available online: http://www.tandfonline.com/10.1080/03007995.2018.1451312.

PY - 2018/4/12

Y1 - 2018/4/12

N2 - Introduction and objectives: Stains have become an integral part of treatment to reduce cardiac events in patients with cardiovascular disease. However, their use within the public healthcare system in Brazil is unknown. Consequently, we sought to determine and characterize statin use in primary healthcare delivered by the public health system (SUS) in Brazil and evaluate associated patient factors to improve future use. Methods: Cross-sectional study with a national representative sample from five Brazilian regions, derived from the National Survey on Access, Use and Promotion of Rational Use of Medicines using a multi-stage complex sampling plan. Patients over 18 years old were interviewed from July/2014 to May/2015. Prevalence of statin use and statins’ self-reported adherence were determined amongst medicine users. The association between statin use and sociodemographic/health condition variables were assessed using logistic regression. Results: 8,803 patients were interviewed; of which, 6,511 were medicines users. The prevalence of statins use was 9.4% with simvastatin (90.3%), atorvastatin (4.7%) and rosuvastatin (1.9%) the most used statins. Poor adherence was described by 6.5% of patients. Statins use was significantly associated with age ≥65 years old, higher educational level, residence in the South, metabolic and heart diseases, alcohol consumption and polypharmacy. Conclusions: This is the first population based study in Brazil to assess statin use in SUS primary healthcare patients. Addressing inequalities in access and use of medicines including statins is an important step in achieving the full benefit of statins in Brazil, with the findings guiding future research and policies.

AB - Introduction and objectives: Stains have become an integral part of treatment to reduce cardiac events in patients with cardiovascular disease. However, their use within the public healthcare system in Brazil is unknown. Consequently, we sought to determine and characterize statin use in primary healthcare delivered by the public health system (SUS) in Brazil and evaluate associated patient factors to improve future use. Methods: Cross-sectional study with a national representative sample from five Brazilian regions, derived from the National Survey on Access, Use and Promotion of Rational Use of Medicines using a multi-stage complex sampling plan. Patients over 18 years old were interviewed from July/2014 to May/2015. Prevalence of statin use and statins’ self-reported adherence were determined amongst medicine users. The association between statin use and sociodemographic/health condition variables were assessed using logistic regression. Results: 8,803 patients were interviewed; of which, 6,511 were medicines users. The prevalence of statins use was 9.4% with simvastatin (90.3%), atorvastatin (4.7%) and rosuvastatin (1.9%) the most used statins. Poor adherence was described by 6.5% of patients. Statins use was significantly associated with age ≥65 years old, higher educational level, residence in the South, metabolic and heart diseases, alcohol consumption and polypharmacy. Conclusions: This is the first population based study in Brazil to assess statin use in SUS primary healthcare patients. Addressing inequalities in access and use of medicines including statins is an important step in achieving the full benefit of statins in Brazil, with the findings guiding future research and policies.

KW - cardiovascular diseases

KW - hypercholesterolemia

KW - statins

KW - primary health care

KW - drug utilisation

KW - Brazil

U2 - 10.1080/03007995.2018.1451312

DO - 10.1080/03007995.2018.1451312

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JO - Current Medical Research and Opinion

JF - Current Medical Research and Opinion

SN - 0300-7995

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Nascimento RCRM, Guerra Júnior AA, Alvares J, Gomes IC, Godman B, Bennie M et al. Statin use in Brazil: findings and implications. Current Medical Research and Opinion. 2018 Apr 12;43(10):1809-1817. Available from, DOI: 10.1080/03007995.2018.1451312