Static mode microfluidic cantilevers for detection of waterborne pathogens

Helen Bridle, Wenxing Wang, Despoina Gavriilidou, Farid Amalou, Duncan P. Hand, Wenmiao Shu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This paper reports on the first demonstration of polymeric microfluidic cantilever sensors. Microcantilever sensors, magnetic beads, and microfluidic technology have been combined to create a polymer based biosensor. Using cheap materials like polyimide, a simple fabrication method has been developed to produce cantilevers with an embedded microfluidic channel. The advantage of this approach is that the addition of a microfluidic channel enables the analysis of smaller volumes and increases the capture efficiency in applications detecting rare analytes. As a proof of principle the system has been applied for the detection of the waterborne protozoan parasite Cryptosporidium, achieving sensitivity comparable to QCM, whereas a previous set-up without the microfluidic channel was unable to detect the parasite.
LanguageEnglish
Pages144-149
Number of pages6
JournalSensors and Actuators A: Physical
Volume247
Early online date6 May 2016
DOIs
Publication statusE-pub ahead of print - 6 May 2016

Fingerprint

pathogens
Pathogens
Microfluidics
parasites
sensors
polyimides
bioinstrumentation
beads
Magnetic sensors
fabrication
Polyimides
Biosensors
sensitivity
polymers
Polymers
Demonstrations
Fabrication
Sensors

Keywords

  • microfluidics
  • cantilever
  • cryptosporidium
  • detection

Cite this

Bridle, Helen ; Wang, Wenxing ; Gavriilidou, Despoina ; Amalou, Farid ; Hand, Duncan P. ; Shu, Wenmiao. / Static mode microfluidic cantilevers for detection of waterborne pathogens. In: Sensors and Actuators A: Physical. 2016 ; Vol. 247. pp. 144-149.
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Static mode microfluidic cantilevers for detection of waterborne pathogens. / Bridle, Helen; Wang, Wenxing; Gavriilidou, Despoina; Amalou, Farid; Hand, Duncan P.; Shu, Wenmiao.

In: Sensors and Actuators A: Physical, Vol. 247, 06.05.2016, p. 144-149.

Research output: Contribution to journalArticle

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AU - Shu, Wenmiao

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AB - This paper reports on the first demonstration of polymeric microfluidic cantilever sensors. Microcantilever sensors, magnetic beads, and microfluidic technology have been combined to create a polymer based biosensor. Using cheap materials like polyimide, a simple fabrication method has been developed to produce cantilevers with an embedded microfluidic channel. The advantage of this approach is that the addition of a microfluidic channel enables the analysis of smaller volumes and increases the capture efficiency in applications detecting rare analytes. As a proof of principle the system has been applied for the detection of the waterborne protozoan parasite Cryptosporidium, achieving sensitivity comparable to QCM, whereas a previous set-up without the microfluidic channel was unable to detect the parasite.

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