State-dependent brainstem ensemble dynamics and their interactions with hippocampus across sleep states

Tomomi Tsunematsu, Amisha A Patel, Arno Onken, Shuzo Sakata

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Abstract

The brainstem plays a crucial role in sleep-wake regulation. However, the ensemble dynamics underlying sleep regulation remain poorly understood. Here, we show slow, state-predictive brainstem ensemble dynamics and state-dependent interactions between the brainstem and the hippocampus in mice. On a timescale of seconds to minutes, brainstem populations can predict pupil dilation and vigilance states and exhibit longer prediction power than hippocampal CA1 neurons. On a timescale of sub-seconds, pontine waves (P-waves) are accompanied by synchronous firing of brainstem neurons during both rapid eye movement (REM) and non-REM (NREM) sleep. Crucially, P-waves functionally interact with CA1 activity in a state-dependent manner: during NREM sleep, hippocampal sharp wave-ripples (SWRs) precede P-waves. On the other hand, P-waves during REM sleep are phase-locked with ongoing theta oscillations and are followed by burst firing of CA1 neurons. This state-dependent global coordination between the brainstem and hippocampus implicates distinct functional roles of sleep.

Original languageEnglish
Article numbere52244
Number of pages22
JournalElife
Volume9
Early online date14 Jan 2020
DOIs
Publication statusPublished - 14 Jan 2020

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Keywords

  • brainstem
  • hippocampus
  • sleep

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