Sphingosine kinase 1 enables communication between melanoma cells and fibroblasts that provides a new link to metastasis

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Abstract

In this issue of Oncogene, Albinet et al. have demonstrated a critical role of melanoma sphingosine kinase 1, which catalyses formation of sphingosine 1-phosphate (S1P), in promoting the differentiation of fibroblasts into myofibroblasts. The myofibroblast sphingosine kinase 1 then promotes the S1P-dependent dissemination (metastasis) of melanoma cells via a S1P receptor 3-mediated mechanism. These findings are of major significance because they provide a novel mechanism of interaction between melanoma and the microenvironment niche in promoting metastasis. These studies therefore identify S1P derived from myofibroblasts and melanoma cells as a novel target for therapeutic intervention.

Original languageEnglish
Pages (from-to)3361-3363
Number of pages3
JournalOncogene
Volume33
Issue number26
DOIs
Publication statusPublished - 26 Jun 2014

Keywords

  • animals
  • female
  • fibroblasts
  • humans
  • melanoma
  • Phosphotransferases (Alcohol Group Acceptor)
  • skin neoplasms

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