Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors

Research output: Contribution to journalSpecial issue

79 Citations (Scopus)

Abstract

Sphingosine 1-phosphate (S1P) is a polar lysophospholipid metabolite that is stored in platelets and released upon their activation. However, diverse stimuli such as growth factors, cytokines, G-protein coupled receptor (GPCR) agonists and antigens have been shown to increase sphingosine kinase activity and S1P formation in other cell types, such as smooth muscle. Indeed, S1P has been implicated in the regulation of several important cellular processes, such as proliferation, differentiation, apoptosis and migration in these cells. Over the past few years, there has been a major advance in our understanding of how S1P can act as an intercellular mediator by binding to a new class of G-protein coupled receptors to regulate cell function. This review focuses on the enzymatic regulation of S1P formation and degradation and its interaction with a novel tethered receptor complex containing the S1P receptor (S1P(1)) and the platelet-derived growth factor (PDGF) beta receptor. This tethered receptor complex enables coincident integrative signalling to p42/p44 MAPK. This is compared with a sequential model in which PDGF promotes S1P release, which in turn acts on S1P(1) to promote Rac signalling.
LanguageEnglish
Pages121-131
Number of pages11
JournalBBA - Biochimica et Biophysica Acta
Volume1582
Issue number1-3
DOIs
Publication statusPublished - 23 May 2002

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Phosphates
Lipids
G-Protein-Coupled Receptors
Lysosphingolipid Receptors
Lysophospholipids
Platelet-Derived Growth Factor beta Receptor
Mitogen-Activated Protein Kinase 3
sphingosine 1-phosphate
Mitogen-Activated Protein Kinase 1
Platelet-Derived Growth Factor
Cell Movement
Smooth Muscle
Intercellular Signaling Peptides and Proteins
Blood Platelets
Apoptosis
Cytokines
Antigens

Keywords

  • animals
  • humans
  • lysophospholipids
  • MAP kinase signaling system
  • models, biological
  • phosphatidate phosphatase
  • phospholipids
  • receptors, cell surface
  • signal transduction
  • sphingosine

Cite this

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title = "Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors",
abstract = "Sphingosine 1-phosphate (S1P) is a polar lysophospholipid metabolite that is stored in platelets and released upon their activation. However, diverse stimuli such as growth factors, cytokines, G-protein coupled receptor (GPCR) agonists and antigens have been shown to increase sphingosine kinase activity and S1P formation in other cell types, such as smooth muscle. Indeed, S1P has been implicated in the regulation of several important cellular processes, such as proliferation, differentiation, apoptosis and migration in these cells. Over the past few years, there has been a major advance in our understanding of how S1P can act as an intercellular mediator by binding to a new class of G-protein coupled receptors to regulate cell function. This review focuses on the enzymatic regulation of S1P formation and degradation and its interaction with a novel tethered receptor complex containing the S1P receptor (S1P(1)) and the platelet-derived growth factor (PDGF) beta receptor. This tethered receptor complex enables coincident integrative signalling to p42/p44 MAPK. This is compared with a sequential model in which PDGF promotes S1P release, which in turn acts on S1P(1) to promote Rac signalling.",
keywords = "animals, humans, lysophospholipids, MAP kinase signaling system, models, biological, phosphatidate phosphatase, phospholipids, receptors, cell surface, signal transduction, sphingosine",
author = "Susan Pyne and Pyne, {Nigel J}",
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Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors. / Pyne, Susan; Pyne, Nigel J.

In: BBA - Biochimica et Biophysica Acta, Vol. 1582, No. 1-3, 23.05.2002, p. 121-131.

Research output: Contribution to journalSpecial issue

TY - JOUR

T1 - Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors

AU - Pyne, Susan

AU - Pyne, Nigel J

PY - 2002/5/23

Y1 - 2002/5/23

N2 - Sphingosine 1-phosphate (S1P) is a polar lysophospholipid metabolite that is stored in platelets and released upon their activation. However, diverse stimuli such as growth factors, cytokines, G-protein coupled receptor (GPCR) agonists and antigens have been shown to increase sphingosine kinase activity and S1P formation in other cell types, such as smooth muscle. Indeed, S1P has been implicated in the regulation of several important cellular processes, such as proliferation, differentiation, apoptosis and migration in these cells. Over the past few years, there has been a major advance in our understanding of how S1P can act as an intercellular mediator by binding to a new class of G-protein coupled receptors to regulate cell function. This review focuses on the enzymatic regulation of S1P formation and degradation and its interaction with a novel tethered receptor complex containing the S1P receptor (S1P(1)) and the platelet-derived growth factor (PDGF) beta receptor. This tethered receptor complex enables coincident integrative signalling to p42/p44 MAPK. This is compared with a sequential model in which PDGF promotes S1P release, which in turn acts on S1P(1) to promote Rac signalling.

AB - Sphingosine 1-phosphate (S1P) is a polar lysophospholipid metabolite that is stored in platelets and released upon their activation. However, diverse stimuli such as growth factors, cytokines, G-protein coupled receptor (GPCR) agonists and antigens have been shown to increase sphingosine kinase activity and S1P formation in other cell types, such as smooth muscle. Indeed, S1P has been implicated in the regulation of several important cellular processes, such as proliferation, differentiation, apoptosis and migration in these cells. Over the past few years, there has been a major advance in our understanding of how S1P can act as an intercellular mediator by binding to a new class of G-protein coupled receptors to regulate cell function. This review focuses on the enzymatic regulation of S1P formation and degradation and its interaction with a novel tethered receptor complex containing the S1P receptor (S1P(1)) and the platelet-derived growth factor (PDGF) beta receptor. This tethered receptor complex enables coincident integrative signalling to p42/p44 MAPK. This is compared with a sequential model in which PDGF promotes S1P release, which in turn acts on S1P(1) to promote Rac signalling.

KW - animals

KW - humans

KW - lysophospholipids

KW - MAP kinase signaling system

KW - models, biological

KW - phosphatidate phosphatase

KW - phospholipids

KW - receptors, cell surface

KW - signal transduction

KW - sphingosine

UR - http://www.journals.elsevier.com/bba-molecular-and-cell-biology-of-lipids

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JO - BBA - Biochimica et Biophysica Acta

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