Sphingosine 1-phosphate receptor 1 signaling in mammalian cells

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The bioactive lipid, sphingosine 1-phosphate (S1P) binds to a family of G protein-coupled receptors, termed S1P1-S1P5. These receptors function in, for example, the cardiovascular system to regulate vascular barrier integrity and tone, the nervous system to regulate neuronal differentiation, myelination and oligodendrocyte/glial cell survival and the immune system to regulate T- and B-cell subsets and trafficking. S1P receptors also participate in the pathophysiology of autoimmunity, inflammatory disease, cancer, neurodegeneration and others. In this review, we describe how S1P1 can form a complex with G-protein and β-arrestin, which function together to regulate effector pathways. We also discuss the role of the S1P1-Platelet derived growth factor receptor β functional complex (which deploys G-protein/β-arrestin and receptor tyrosine kinase signaling) in regulating cell migration. Possible mechanisms by which different S1P-chaperones, such as Apolipoprotein M-High-Density Lipoprotein induce biological programmes in cells are also described. Finally, the role of S1P1 in health and disease and as a target for clinical intervention is appraised.
LanguageEnglish
Article number344
Pages1-18
Number of pages18
JournalMolecules
Volume22
Issue number3
DOIs
Publication statusPublished - 23 Feb 2017

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Lysosphingolipid Receptors
Arrestin
GTP-Binding Proteins
phosphates
Cells
Platelet-Derived Growth Factor beta Receptor
B-Lymphocyte Subsets
Cardiovascular system
Apolipoproteins
Immune system
Oligodendroglia
Receptor Protein-Tyrosine Kinases
Neurology
T-Lymphocyte Subsets
HDL Lipoproteins
G-Protein-Coupled Receptors
Cardiovascular System
Autoimmunity
Neuroglia
Nervous System

Keywords

  • sphingosine 1-phosphate
  • G-protein coupled receptor
  • megaplex
  • receptor tyrosine kinase
  • immune trafficking
  • neovascularisation
  • cardiovascular;
  • cancer

Cite this

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title = "Sphingosine 1-phosphate receptor 1 signaling in mammalian cells",
abstract = "The bioactive lipid, sphingosine 1-phosphate (S1P) binds to a family of G protein-coupled receptors, termed S1P1-S1P5. These receptors function in, for example, the cardiovascular system to regulate vascular barrier integrity and tone, the nervous system to regulate neuronal differentiation, myelination and oligodendrocyte/glial cell survival and the immune system to regulate T- and B-cell subsets and trafficking. S1P receptors also participate in the pathophysiology of autoimmunity, inflammatory disease, cancer, neurodegeneration and others. In this review, we describe how S1P1 can form a complex with G-protein and β-arrestin, which function together to regulate effector pathways. We also discuss the role of the S1P1-Platelet derived growth factor receptor β functional complex (which deploys G-protein/β-arrestin and receptor tyrosine kinase signaling) in regulating cell migration. Possible mechanisms by which different S1P-chaperones, such as Apolipoprotein M-High-Density Lipoprotein induce biological programmes in cells are also described. Finally, the role of S1P1 in health and disease and as a target for clinical intervention is appraised.",
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Sphingosine 1-phosphate receptor 1 signaling in mammalian cells. / Pyne, Nigel J.; Pyne, Susan.

In: Molecules, Vol. 22, No. 3, 344, 23.02.2017, p. 1-18.

Research output: Contribution to journalArticle

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AU - Pyne, Susan

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