Sphingosine 1-phosphate, lysophosphatidic acid and growth factor signaling and termination

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33 Citations (Scopus)

Abstract

Sphingosine 1 phosphate (S1P) and lysophosphatidic acid (LPA) are bioactive lipid phosphates that bind to cell surface G-protein coupled receptors (GPCR) and, in addition, exhibit intracellular actions. We have summarised herein, an important functional interaction between lipid phosphate GPCR and receptor tyrosine kinases (RTK) that enables growth factors to spatially regulate effectors, thereby governing the nature of the biological response. For instance, we describe how the formation of functional complexes between the S1P1 receptor and PDGFβ receptor may effectively re-programme platelet-derived growth factor from a mitogenic to a migratory stimulus. This is achieved by integration of RTK- and GPCR-specific signals that results in spatial regulation of a cytoplasmic retained pool of extracellular signal regulated kinase-1/2 linked to myosin light chain kinase, myosin light chain phosphorylation and migration. We therefore suggest that the lipid phosphate receptor is a major determinant in regulating growth factor-dependent biology. Growth factors can also increase S1P inside cells, and we discuss the concept of spatial/temporal aspects of compartmentalised intracellular signaling of S1P in relation to defined interactions between, for instance, sphingosine kinase, phospholipase D1 and lipid phosphate phosphatases and regulation of cell survival.
LanguageEnglish
Pages467-476
Number of pages9
JournalBiochimica et Biophysica Acta Molecular and Cell Biology of Lipids
Volume1781
Issue number9
DOIs
Publication statusPublished - 2008

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G-Protein-Coupled Receptors
Intercellular Signaling Peptides and Proteins
Phosphates
Receptor Protein-Tyrosine Kinases
Lipids
Lysosphingolipid Receptors
Myosin-Light-Chain Kinase
Myosin Light Chains
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Platelet-Derived Growth Factor
Emigration and Immigration
Cell Survival
Membrane Proteins
Phosphorylation
lysophosphatidic acid
sphingosine 1-phosphate

Keywords

  • sphingosine 1-phosphate
  • lysophospatidic acid
  • PDGF
  • NGF
  • growth factor
  • lipid phosphate phosphatase
  • sphingosine kinase
  • phospholipase D
  • integrative signalling

Cite this

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title = "Sphingosine 1-phosphate, lysophosphatidic acid and growth factor signaling and termination",
abstract = "Sphingosine 1 phosphate (S1P) and lysophosphatidic acid (LPA) are bioactive lipid phosphates that bind to cell surface G-protein coupled receptors (GPCR) and, in addition, exhibit intracellular actions. We have summarised herein, an important functional interaction between lipid phosphate GPCR and receptor tyrosine kinases (RTK) that enables growth factors to spatially regulate effectors, thereby governing the nature of the biological response. For instance, we describe how the formation of functional complexes between the S1P1 receptor and PDGFβ receptor may effectively re-programme platelet-derived growth factor from a mitogenic to a migratory stimulus. This is achieved by integration of RTK- and GPCR-specific signals that results in spatial regulation of a cytoplasmic retained pool of extracellular signal regulated kinase-1/2 linked to myosin light chain kinase, myosin light chain phosphorylation and migration. We therefore suggest that the lipid phosphate receptor is a major determinant in regulating growth factor-dependent biology. Growth factors can also increase S1P inside cells, and we discuss the concept of spatial/temporal aspects of compartmentalised intracellular signaling of S1P in relation to defined interactions between, for instance, sphingosine kinase, phospholipase D1 and lipid phosphate phosphatases and regulation of cell survival.",
keywords = "sphingosine 1-phosphate, lysophospatidic acid, PDGF, NGF, growth factor, lipid phosphate phosphatase, sphingosine kinase, phospholipase D, integrative signalling",
author = "N.J. Pyne and S. Pyne",
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doi = "10.1016/j.bbalip.2008.05.004",
language = "English",
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pages = "467--476",
journal = "Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids",
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TY - JOUR

T1 - Sphingosine 1-phosphate, lysophosphatidic acid and growth factor signaling and termination

AU - Pyne, N.J.

AU - Pyne, S.

PY - 2008

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N2 - Sphingosine 1 phosphate (S1P) and lysophosphatidic acid (LPA) are bioactive lipid phosphates that bind to cell surface G-protein coupled receptors (GPCR) and, in addition, exhibit intracellular actions. We have summarised herein, an important functional interaction between lipid phosphate GPCR and receptor tyrosine kinases (RTK) that enables growth factors to spatially regulate effectors, thereby governing the nature of the biological response. For instance, we describe how the formation of functional complexes between the S1P1 receptor and PDGFβ receptor may effectively re-programme platelet-derived growth factor from a mitogenic to a migratory stimulus. This is achieved by integration of RTK- and GPCR-specific signals that results in spatial regulation of a cytoplasmic retained pool of extracellular signal regulated kinase-1/2 linked to myosin light chain kinase, myosin light chain phosphorylation and migration. We therefore suggest that the lipid phosphate receptor is a major determinant in regulating growth factor-dependent biology. Growth factors can also increase S1P inside cells, and we discuss the concept of spatial/temporal aspects of compartmentalised intracellular signaling of S1P in relation to defined interactions between, for instance, sphingosine kinase, phospholipase D1 and lipid phosphate phosphatases and regulation of cell survival.

AB - Sphingosine 1 phosphate (S1P) and lysophosphatidic acid (LPA) are bioactive lipid phosphates that bind to cell surface G-protein coupled receptors (GPCR) and, in addition, exhibit intracellular actions. We have summarised herein, an important functional interaction between lipid phosphate GPCR and receptor tyrosine kinases (RTK) that enables growth factors to spatially regulate effectors, thereby governing the nature of the biological response. For instance, we describe how the formation of functional complexes between the S1P1 receptor and PDGFβ receptor may effectively re-programme platelet-derived growth factor from a mitogenic to a migratory stimulus. This is achieved by integration of RTK- and GPCR-specific signals that results in spatial regulation of a cytoplasmic retained pool of extracellular signal regulated kinase-1/2 linked to myosin light chain kinase, myosin light chain phosphorylation and migration. We therefore suggest that the lipid phosphate receptor is a major determinant in regulating growth factor-dependent biology. Growth factors can also increase S1P inside cells, and we discuss the concept of spatial/temporal aspects of compartmentalised intracellular signaling of S1P in relation to defined interactions between, for instance, sphingosine kinase, phospholipase D1 and lipid phosphate phosphatases and regulation of cell survival.

KW - sphingosine 1-phosphate

KW - lysophospatidic acid

KW - PDGF

KW - NGF

KW - growth factor

KW - lipid phosphate phosphatase

KW - sphingosine kinase

KW - phospholipase D

KW - integrative signalling

UR - http://www.journals.elsevier.com/bba-molecular-and-cell-biology-of-lipids

U2 - 10.1016/j.bbalip.2008.05.004

DO - 10.1016/j.bbalip.2008.05.004

M3 - Special issue

VL - 1781

SP - 467

EP - 476

JO - Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids

T2 - Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids

SN - 1388-1981

IS - 9

ER -