Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine
kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-kappaB/IL-6/STAT3 pathway. This
appears critical for progression from chronic inflammation to colon cancer.
Original languageEnglish
Pages (from-to)5-7
Number of pages3
JournalCancer Cell
Volume23
Issue number1
DOIs
Publication statusPublished - 14 Jan 2013

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Lysosphingolipid Receptors
NF-kappa B
Colonic Neoplasms
Interleukin-6
Inflammation
Lipids
Enzymes
Neoplasms
sphingosine kinase
sphingosine 1-phosphate

Keywords

  • sphingosine 1-phosphate
  • missing link
  • chronic inflammation
  • colon cancer

Cite this

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title = "Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer",
abstract = "In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-kappaB/IL-6/STAT3 pathway. Thisappears critical for progression from chronic inflammation to colon cancer.",
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Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer. / Pyne, Susan; Pyne, Nigel.

In: Cancer Cell, Vol. 23, No. 1, 14.01.2013, p. 5-7.

Research output: Contribution to journalArticle

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