Abstract
In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine
kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-kappaB/IL-6/STAT3 pathway. This
appears critical for progression from chronic inflammation to colon cancer.
kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-kappaB/IL-6/STAT3 pathway. This
appears critical for progression from chronic inflammation to colon cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 5-7 |
| Number of pages | 3 |
| Journal | Cancer Cell |
| Volume | 23 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 14 Jan 2013 |
Keywords
- sphingosine 1-phosphate
- missing link
- chronic inflammation
- colon cancer