Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer

Susan Pyne; Nigel Pyne

doi:10.1016/j.ccr.2012.12.005

Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer

Susan Pyne, Nigel Pyne

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine
kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-kappaB/IL-6/STAT3 pathway. This
appears critical for progression from chronic inflammation to colon cancer.

Original language	English
Pages (from-to)	5-7
Number of pages	3
Journal	Cancer Cell
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.ccr.2012.12.005
Publication status	Published - 14 Jan 2013

Keywords

sphingosine 1-phosphate
missing link
chronic inflammation
colon cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccr.2012.12.005

Cite this

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title = "Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer",

abstract = "In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-kappaB/IL-6/STAT3 pathway. Thisappears critical for progression from chronic inflammation to colon cancer.",

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AB - In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-kappaB/IL-6/STAT3 pathway. Thisappears critical for progression from chronic inflammation to colon cancer.

KW - sphingosine 1-phosphate

KW - missing link

KW - chronic inflammation

KW - colon cancer

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SN - 1535-6108

IS - 1

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Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer

Abstract

Keywords

UN SDGs

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