Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer

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In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine
kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-kappaB/IL-6/STAT3 pathway. This
appears critical for progression from chronic inflammation to colon cancer.
Original languageEnglish
Pages (from-to)5-7
Number of pages3
JournalCancer Cell
Issue number1
Publication statusPublished - 14 Jan 2013


  • sphingosine 1-phosphate
  • missing link
  • chronic inflammation
  • colon cancer

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