Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer

Susan Pyne, Nigel Pyne

Research output: Contribution to journal › Article

22 Citations (Scopus)

Abstract

In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine
kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-kappaB/IL-6/STAT3 pathway. This
appears critical for progression from chronic inflammation to colon cancer.
Original languageEnglish
Pages (from-to)5-7
Number of pages3
JournalCancer Cell
Volume23
Issue number1
DOIs
Publication statusPublished - 14 Jan 2013

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Lysosphingolipid Receptors
NF-kappa B
Colonic Neoplasms
Interleukin-6
Inflammation
Lipids
Enzymes
Neoplasms
sphingosine kinase
sphingosine 1-phosphate

Keywords

  • sphingosine 1-phosphate
  • missing link
  • chronic inflammation
  • colon cancer

Cite this

Pyne, Susan ; Pyne, Nigel. / Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer. In: Cancer Cell. 2013 ; Vol. 23, No. 1. pp. 5-7.
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Pyne, S & Pyne, N 2013, 'Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer', Cancer Cell, vol. 23, no. 1, pp. 5-7. https://doi.org/10.1016/j.ccr.2012.12.005

Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer. / Pyne, Susan; Pyne, Nigel.

In: Cancer Cell, Vol. 23, No. 1, 14.01.2013, p. 5-7.

Research output: Contribution to journal › Article

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T1 - Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer

AU - Pyne, Susan

AU - Pyne, Nigel

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N2 - In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-kappaB/IL-6/STAT3 pathway. Thisappears critical for progression from chronic inflammation to colon cancer.

AB - In this issue of Cancer Cell, Liang and colleagues demonstrated that sphingosine kinase 1, the enzyme that catalyzes formation of the biologically active lipid sphingosine 1-phosphate, drives a malicious amplification loop involving sphingosine 1-phosphate receptor 1 and the NF-kappaB/IL-6/STAT3 pathway. Thisappears critical for progression from chronic inflammation to colon cancer.

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KW - chronic inflammation

KW - colon cancer

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Pyne S, Pyne N. Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer. Cancer Cell. 2013 Jan 14;23(1):5-7. https://doi.org/10.1016/j.ccr.2012.12.005

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