Sphingosine 1-phosphate and cancer

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Abstract

There is substantial evidence that sphingosine 1-phosphate (S1P) is involved in cancer. S1P regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival. This occurs at multiple levels and involves S1P receptors, sphingosine kinases, S1P phosphatases and S1P lyase. This Review summarizes current research findings and examines the potential for new therapeutics designed to alter S1P signalling and function in cancer.
Original languageEnglish
Pages (from-to)489-503
Number of pages15
JournalNature Reviews Cancer
Volume10
Issue number7
DOIs
Publication statusPublished - Jul 2010

Keywords

  • sphingosine 1-phosphate
  • cancer
  • neovascularization
  • inflammation

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