Abstract
Sphingomyelin is a phospholipid that is preferentially located in the outer leaflet of the plasma membrane of mammalian cells. It can be hydrolysed by three distinct isoforms of a phospholipase C (PLC)-like enzyme, sphingomyelinase,
which are distinguished by their pH optima and Mg2+-dependence. Activation of sphingomyelinase occurs in response to stimulation of a number of distinct cell-surface receptors by a variety of biological agonists, such as cytokines
and growth factors [l]. Several metabolites of sphingomyelin have been identified as potential second-messenger molecules.
which are distinguished by their pH optima and Mg2+-dependence. Activation of sphingomyelinase occurs in response to stimulation of a number of distinct cell-surface receptors by a variety of biological agonists, such as cytokines
and growth factors [l]. Several metabolites of sphingomyelin have been identified as potential second-messenger molecules.
Original language | English |
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Pages (from-to) | 549-556 |
Number of pages | 8 |
Journal | Biochemical Society Transactions |
Volume | 25 |
Issue number | 2 |
DOIs | |
Publication status | Published - May 1997 |
Keywords
- protein-kinase
- phospholipase-D activation
- phosphatidic-acid levels
- dependent activation
- signaling pathways
- kappa-b
- sphingosine