Sphingolipids as differential regulators of cellular signalling processes

S Pyne, D G Tolan, A M Conway, N Pyne

Research output: Contribution to journalLiterature review

23 Citations (Scopus)

Abstract

Sphingomyelin is a phospholipid that is preferentially located in the outer leaflet of the plasma membrane of mammalian cells. It can be hydrolysed by three distinct isoforms of a phospholipase C (PLC)-like enzyme, sphingomyelinase,
which are distinguished by their pH optima and Mg2+-dependence. Activation of sphingomyelinase occurs in response to stimulation of a number of distinct cell-surface receptors by a variety of biological agonists, such as cytokines
and growth factors [l]. Several metabolites of sphingomyelin have been identified as potential second-messenger molecules.
LanguageEnglish
Pages549-556
Number of pages8
JournalBiochemical Society Transactions
Volume25
Issue number2
DOIs
Publication statusPublished - May 1997

Fingerprint

Cell signaling
Sphingomyelin Phosphodiesterase
Sphingolipids
Sphingomyelins
Cell Surface Receptors
Type C Phospholipases
Second Messenger Systems
Cell membranes
Metabolites
Phospholipids
Intercellular Signaling Peptides and Proteins
Protein Isoforms
Chemical activation
Cells
Cell Membrane
Molecules
Enzymes

Keywords

  • protein-kinase
  • phospholipase-D activation
  • phosphatidic-acid levels
  • dependent activation
  • signaling pathways
  • kappa-b
  • sphingosine

Cite this

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abstract = "Sphingomyelin is a phospholipid that is preferentially located in the outer leaflet of the plasma membrane of mammalian cells. It can be hydrolysed by three distinct isoforms of a phospholipase C (PLC)-like enzyme, sphingomyelinase,which are distinguished by their pH optima and Mg2+-dependence. Activation of sphingomyelinase occurs in response to stimulation of a number of distinct cell-surface receptors by a variety of biological agonists, such as cytokinesand growth factors [l]. Several metabolites of sphingomyelin have been identified as potential second-messenger molecules.",
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Sphingolipids as differential regulators of cellular signalling processes. / Pyne, S ; Tolan, D G ; Conway, A M ; Pyne, N .

In: Biochemical Society Transactions, Vol. 25, No. 2, 05.1997, p. 549-556.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - Sphingolipids as differential regulators of cellular signalling processes

AU - Pyne, S

AU - Tolan, D G

AU - Conway, A M

AU - Pyne, N

PY - 1997/5

Y1 - 1997/5

N2 - Sphingomyelin is a phospholipid that is preferentially located in the outer leaflet of the plasma membrane of mammalian cells. It can be hydrolysed by three distinct isoforms of a phospholipase C (PLC)-like enzyme, sphingomyelinase,which are distinguished by their pH optima and Mg2+-dependence. Activation of sphingomyelinase occurs in response to stimulation of a number of distinct cell-surface receptors by a variety of biological agonists, such as cytokinesand growth factors [l]. Several metabolites of sphingomyelin have been identified as potential second-messenger molecules.

AB - Sphingomyelin is a phospholipid that is preferentially located in the outer leaflet of the plasma membrane of mammalian cells. It can be hydrolysed by three distinct isoforms of a phospholipase C (PLC)-like enzyme, sphingomyelinase,which are distinguished by their pH optima and Mg2+-dependence. Activation of sphingomyelinase occurs in response to stimulation of a number of distinct cell-surface receptors by a variety of biological agonists, such as cytokinesand growth factors [l]. Several metabolites of sphingomyelin have been identified as potential second-messenger molecules.

KW - protein-kinase

KW - phospholipase-D activation

KW - phosphatidic-acid levels

KW - dependent activation

KW - signaling pathways

KW - kappa-b

KW - sphingosine

UR - http://www.biochemsoctrans.org/bst/

U2 - 10.1042/bst0250549

DO - 10.1042/bst0250549

M3 - Literature review

VL - 25

SP - 549

EP - 556

JO - Biochemical Society Transactions

T2 - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

IS - 2

ER -