Sphingolipids as differential regulators of cellular signalling processes

S Pyne, D G Tolan, A M Conway, N Pyne

Research output: Contribution to journalLiterature reviewpeer-review

26 Citations (Scopus)


Sphingomyelin is a phospholipid that is preferentially located in the outer leaflet of the plasma membrane of mammalian cells. It can be hydrolysed by three distinct isoforms of a phospholipase C (PLC)-like enzyme, sphingomyelinase,
which are distinguished by their pH optima and Mg2+-dependence. Activation of sphingomyelinase occurs in response to stimulation of a number of distinct cell-surface receptors by a variety of biological agonists, such as cytokines
and growth factors [l]. Several metabolites of sphingomyelin have been identified as potential second-messenger molecules.
Original languageEnglish
Pages (from-to)549-556
Number of pages8
JournalBiochemical Society Transactions
Issue number2
Publication statusPublished - May 1997


  • protein-kinase
  • phospholipase-D activation
  • phosphatidic-acid levels
  • dependent activation
  • signaling pathways
  • kappa-b
  • sphingosine


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