TY - JOUR
T1 - Spectroscopic detection of a therapeutic drug in the mammalian eye
AU - Miller, J.
AU - Wilson, W.S.
AU - Kek, W.K.
AU - Wilson, C.G.
AU - Uttamchandani, D.G.
PY - 2003
Y1 - 2003
N2 - We have developed a novel and fast ocular spectrometer and demonstrated its ability to perform real time spectroscopic measurements in the mammalian eye. The instrument comprises a hand-held sensor head which, when placed on the cornea, effectively turns the anterior chamber into a cuvette. This sensor head is connected to the rest of the instrument via two optical fibers. Ex vivo and in vivo evaluation demonstrated the ability of the instrument to detect compounds via both absorption and fluorescence spectroscopy. In vivo evaluation demonstrated the ability of the instrument to detect brimonidine in the cornea and aqueous humor of rabbit eyes.
AB - We have developed a novel and fast ocular spectrometer and demonstrated its ability to perform real time spectroscopic measurements in the mammalian eye. The instrument comprises a hand-held sensor head which, when placed on the cornea, effectively turns the anterior chamber into a cuvette. This sensor head is connected to the rest of the instrument via two optical fibers. Ex vivo and in vivo evaluation demonstrated the ability of the instrument to detect compounds via both absorption and fluorescence spectroscopy. In vivo evaluation demonstrated the ability of the instrument to detect brimonidine in the cornea and aqueous humor of rabbit eyes.
KW - contact lens design
KW - intraocular drug detection
KW - ophthalmic instrumentation
KW - optoelectronic instrumentation
KW - spectroscopy
UR - http://cmp.eee.strath.ac.uk/miller_jstqe_2003.pdf
UR - http://dx.doi.org/10.1109/JSTQE.2003.813315
U2 - 10.1109/JSTQE.2003.813315
DO - 10.1109/JSTQE.2003.813315
M3 - Article
VL - 9
SP - 171
EP - 176
JO - IEEE Journal of Selected Topics in Quantum Electronics
JF - IEEE Journal of Selected Topics in Quantum Electronics
SN - 1077-260X
IS - 2
ER -