Spectroscopic detection of a therapeutic drug in the mammalian eye

J. Miller, W.S. Wilson, W.K. Kek, C.G. Wilson, D.G. Uttamchandani

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We have developed a novel and fast ocular spectrometer and demonstrated its ability to perform real time spectroscopic measurements in the mammalian eye. The instrument comprises a hand-held sensor head which, when placed on the cornea, effectively turns the anterior chamber into a cuvette. This sensor head is connected to the rest of the instrument via two optical fibers. Ex vivo and in vivo evaluation demonstrated the ability of the instrument to detect compounds via both absorption and fluorescence spectroscopy. In vivo evaluation demonstrated the ability of the instrument to detect brimonidine in the cornea and aqueous humor of rabbit eyes.
Original languageEnglish
Pages (from-to)171-176
Number of pages5
JournalIEEE Journal of Selected Topics in Quantum Electronics
Volume9
Issue number2
DOIs
Publication statusPublished - 2003

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Keywords

  • contact lens design
  • intraocular drug detection
  • ophthalmic instrumentation
  • optoelectronic instrumentation
  • spectroscopy

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