Spectroscopic detection of a therapeutic drug in the mammalian eye

J. Miller; W.S. Wilson; W.K. Kek; C.G. Wilson; D.G. Uttamchandani

doi:10.1109/JSTQE.2003.813315

Spectroscopic detection of a therapeutic drug in the mammalian eye

J. Miller, W.S. Wilson, W.K. Kek, C.G. Wilson, D.G. Uttamchandani

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

We have developed a novel and fast ocular spectrometer and demonstrated its ability to perform real time spectroscopic measurements in the mammalian eye. The instrument comprises a hand-held sensor head which, when placed on the cornea, effectively turns the anterior chamber into a cuvette. This sensor head is connected to the rest of the instrument via two optical fibers. Ex vivo and in vivo evaluation demonstrated the ability of the instrument to detect compounds via both absorption and fluorescence spectroscopy. In vivo evaluation demonstrated the ability of the instrument to detect brimonidine in the cornea and aqueous humor of rabbit eyes.

Original language	English
Pages (from-to)	171-176
Number of pages	5
Journal	IEEE Journal of Selected Topics in Quantum Electronics
Volume	9
Issue number	2
DOIs	https://doi.org/10.1109/JSTQE.2003.813315
Publication status	Published - 2003

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Keywords

contact lens design
intraocular drug detection
ophthalmic instrumentation
optoelectronic instrumentation
spectroscopy

Cite this

Miller, J., Wilson, W. S., Kek, W. K., Wilson, C. G., & Uttamchandani, D. G. (2003). Spectroscopic detection of a therapeutic drug in the mammalian eye. IEEE Journal of Selected Topics in Quantum Electronics, 9(2), 171-176. https://doi.org/10.1109/JSTQE.2003.813315

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AB - We have developed a novel and fast ocular spectrometer and demonstrated its ability to perform real time spectroscopic measurements in the mammalian eye. The instrument comprises a hand-held sensor head which, when placed on the cornea, effectively turns the anterior chamber into a cuvette. This sensor head is connected to the rest of the instrument via two optical fibers. Ex vivo and in vivo evaluation demonstrated the ability of the instrument to detect compounds via both absorption and fluorescence spectroscopy. In vivo evaluation demonstrated the ability of the instrument to detect brimonidine in the cornea and aqueous humor of rabbit eyes.

KW - contact lens design

KW - intraocular drug detection

KW - ophthalmic instrumentation

KW - optoelectronic instrumentation

KW - spectroscopy

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Access to Document

10.1109/JSTQE.2003.813315