Spectral analysis of EEG coherence in Alzheimer's disease

P L Calderon-Gonzalez, Mario A. Parra Rodriguez, J J Llibre-Rodriguez, J V Gutierrez

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8 Citations (Scopus)

Abstract

Introduction. In analysis of the electrical activity of the brain, coherence is a measure of the degree of synchrony between two or more regions of the brain with regard to their frequency values over a unit of time. Aims. To explore the functional alterations caused by Alzheimer's disease (AD), by evaluating the behaviour of coherence over the whole spectrum of EEG frequencies. Patients and methods. We studied a group of 42 patients with AD, according to criteria of the NINCDS-ADRDA group. Partial coherence (e.g. between two derivations each time) was calculated within and between hemispheres, during a state of mental rest; the Z statistic was also determined by comparing the coherence values with the standard data for age, sex and functional state of the brain. Results. Significantly low coherence values were obtained for the frontal-central regions of the left hemisphere (LH) and for the occipital-parietal regions of the right hemisphere (RH) in the delta band The same localisations were carried out for the theta band, in addition to the centrotemporal and temporal regions of the LH The highest incoherence values were observed for the alpha and beta bands, more specifically in frontal-central and occipital-parietal derivations of the RH, and temporal derivations of the LH. Conclusions. Non-activated partial coherence acts as an indicator of the degree of functional disconnection between brain regions in AD. Studying activated coherence in these patients could contribute new elements to our knowledge about the functional disorders observed in this disease.
LanguageEnglish
Pages422-427
Number of pages6
JournalRevista de neurologia
Volume38
Issue number5
Publication statusPublished - 1 Mar 2004

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Electroencephalography
Alzheimer Disease
Brain
Occipital Lobe
Parietal Lobe
Temporal Lobe

Keywords

  • spectral analysis
  • EEG coherence
  • Alzheimer's disease
  • functional alterations

Cite this

Calderon-Gonzalez, P. L., Parra Rodriguez, M. A., Llibre-Rodriguez, J. J., & Gutierrez, J. V. (2004). Spectral analysis of EEG coherence in Alzheimer's disease. 38(5), 422-427.
Calderon-Gonzalez, P L ; Parra Rodriguez, Mario A. ; Llibre-Rodriguez, J J ; Gutierrez, J V. / Spectral analysis of EEG coherence in Alzheimer's disease. 2004 ; Vol. 38, No. 5. pp. 422-427.
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Calderon-Gonzalez, PL, Parra Rodriguez, MA, Llibre-Rodriguez, JJ & Gutierrez, JV 2004, 'Spectral analysis of EEG coherence in Alzheimer's disease' vol. 38, no. 5, pp. 422-427.

Spectral analysis of EEG coherence in Alzheimer's disease. / Calderon-Gonzalez, P L; Parra Rodriguez, Mario A.; Llibre-Rodriguez, J J; Gutierrez, J V.

Vol. 38, No. 5, 01.03.2004, p. 422-427.

Research output: Contribution to journalArticle

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AU - Calderon-Gonzalez, P L

AU - Parra Rodriguez, Mario A.

AU - Llibre-Rodriguez, J J

AU - Gutierrez, J V

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AB - Introduction. In analysis of the electrical activity of the brain, coherence is a measure of the degree of synchrony between two or more regions of the brain with regard to their frequency values over a unit of time. Aims. To explore the functional alterations caused by Alzheimer's disease (AD), by evaluating the behaviour of coherence over the whole spectrum of EEG frequencies. Patients and methods. We studied a group of 42 patients with AD, according to criteria of the NINCDS-ADRDA group. Partial coherence (e.g. between two derivations each time) was calculated within and between hemispheres, during a state of mental rest; the Z statistic was also determined by comparing the coherence values with the standard data for age, sex and functional state of the brain. Results. Significantly low coherence values were obtained for the frontal-central regions of the left hemisphere (LH) and for the occipital-parietal regions of the right hemisphere (RH) in the delta band The same localisations were carried out for the theta band, in addition to the centrotemporal and temporal regions of the LH The highest incoherence values were observed for the alpha and beta bands, more specifically in frontal-central and occipital-parietal derivations of the RH, and temporal derivations of the LH. Conclusions. Non-activated partial coherence acts as an indicator of the degree of functional disconnection between brain regions in AD. Studying activated coherence in these patients could contribute new elements to our knowledge about the functional disorders observed in this disease.

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Calderon-Gonzalez PL, Parra Rodriguez MA, Llibre-Rodriguez JJ, Gutierrez JV. Spectral analysis of EEG coherence in Alzheimer's disease. 2004 Mar 1;38(5):422-427.