Spatial aspects of signalling by sphingosine 1-phosphate

S. Pyne; S.C. Lee; J. Long; L. Gillies; N.J. Pyne

doi:10.1007/s00210-009-0430-z

Spatial aspects of signalling by sphingosine 1-phosphate

S. Pyne, S.C. Lee, J. Long, L. Gillies, N.J. Pyne

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Conference Contribution › peer-review

Abstract

Sphingosine kinase (SK) catalyses the phosphorylation of sphingosine to produce sphingosine 1-phosphate (S1P). S1P is a bioactive lipid that regulates cell proliferation, survival, migration etc. Extracellular S1P mediates its effects by binding to a family of five closely related G protein coupled receptors, S1P1-5. In addition, intracellular S1P may bind to undefined intracellular targets to elicit cellular responses. The focus of our recent work has

Original language	English
Pages (from-to)	369-369
Number of pages	0
Journal	Naunyn-Schmiedeberg's Archives of Pharmacology
Volume	380
Issue number	4
DOIs	https://doi.org/10.1007/s00210-009-0430-z
Publication status	Published - Oct 2009

Keywords

spatial aspect
s signalling
sphingosine 1-phosphate

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10.1007/s00210-009-0430-z

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abstract = "Sphingosine kinase (SK) catalyses the phosphorylation of sphingosine to produce sphingosine 1-phosphate (S1P). S1P is a bioactive lipid that regulates cell proliferation, survival, migration etc. Extracellular S1P mediates its effects by binding to a family of five closely related G protein coupled receptors, S1P1-5. In addition, intracellular S1P may bind to undefined intracellular targets to elicit cellular responses. The focus of our recent work has",

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AU - Pyne, S.

AU - Lee, S.C.

AU - Long, J.

AU - Gillies, L.

AU - Pyne, N.J.

PY - 2009/10

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N2 - Sphingosine kinase (SK) catalyses the phosphorylation of sphingosine to produce sphingosine 1-phosphate (S1P). S1P is a bioactive lipid that regulates cell proliferation, survival, migration etc. Extracellular S1P mediates its effects by binding to a family of five closely related G protein coupled receptors, S1P1-5. In addition, intracellular S1P may bind to undefined intracellular targets to elicit cellular responses. The focus of our recent work has

AB - Sphingosine kinase (SK) catalyses the phosphorylation of sphingosine to produce sphingosine 1-phosphate (S1P). S1P is a bioactive lipid that regulates cell proliferation, survival, migration etc. Extracellular S1P mediates its effects by binding to a family of five closely related G protein coupled receptors, S1P1-5. In addition, intracellular S1P may bind to undefined intracellular targets to elicit cellular responses. The focus of our recent work has

KW - spatial aspect

KW - s signalling

KW - sphingosine 1-phosphate

U2 - 10.1007/s00210-009-0430-z

DO - 10.1007/s00210-009-0430-z

M3 - Conference Contribution

VL - 380

SP - 369

EP - 369

JO - Naunyn-Schmiedeberg's Archives of Pharmacology

JF - Naunyn-Schmiedeberg's Archives of Pharmacology

IS - 4

ER -

Spatial aspects of signalling by sphingosine 1-phosphate

Abstract

Keywords

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