Spatial aspects of signalling by sphingosine 1-phosphate

S. Pyne, S.C. Lee, J. Long, L. Gillies, N.J. Pyne

Research output: Contribution to journalConference Contributionpeer-review


Sphingosine kinase (SK) catalyses the phosphorylation of sphingosine to produce sphingosine 1-phosphate (S1P). S1P is a bioactive lipid that regulates cell proliferation, survival, migration etc. Extracellular S1P mediates its effects by binding to a family of five closely related G protein coupled receptors, S1P1-5. In addition, intracellular S1P may bind to undefined intracellular targets to elicit cellular responses. The focus of our recent work has
Original languageEnglish
Pages (from-to)369-369
Number of pages0
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Issue number4
Publication statusPublished - Oct 2009


  • spatial aspect
  • s signalling
  • sphingosine 1-phosphate


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