Spatial aspects of signalling by sphingosine 1-phosphate

S. Pyne, S.C. Lee, J. Long, L. Gillies, N.J. Pyne

Research output: Contribution to journalConference Contribution

Abstract

Sphingosine kinase (SK) catalyses the phosphorylation of sphingosine to produce sphingosine 1-phosphate (S1P). S1P is a bioactive lipid that regulates cell proliferation, survival, migration etc. Extracellular S1P mediates its effects by binding to a family of five closely related G protein coupled receptors, S1P1-5. In addition, intracellular S1P may bind to undefined intracellular targets to elicit cellular responses. The focus of our recent work has
LanguageEnglish
Pages369-369
Number of pages0
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume380
Issue number4
DOIs
Publication statusPublished - Oct 2009

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G-Protein-Coupled Receptors
Cell Survival
Phosphorylation
Cell Proliferation
Lipids
sphingosine 1-phosphate
sphingosine kinase

Keywords

  • spatial aspect
  • s signalling
  • sphingosine 1-phosphate

Cite this

Pyne, S. ; Lee, S.C. ; Long, J. ; Gillies, L. ; Pyne, N.J. / Spatial aspects of signalling by sphingosine 1-phosphate. In: Naunyn-Schmiedeberg's Archives of Pharmacology . 2009 ; Vol. 380, No. 4. pp. 369-369.
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Spatial aspects of signalling by sphingosine 1-phosphate. / Pyne, S.; Lee, S.C.; Long, J.; Gillies, L.; Pyne, N.J.

In: Naunyn-Schmiedeberg's Archives of Pharmacology , Vol. 380, No. 4, 10.2009, p. 369-369.

Research output: Contribution to journalConference Contribution

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AU - Pyne, S.

AU - Lee, S.C.

AU - Long, J.

AU - Gillies, L.

AU - Pyne, N.J.

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KW - s signalling

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