Sono-magnetic heating in tumor phantom

Katarzyna Kaczmarek, Tomasz Hornowski, Iryna Antal, Michal Rajnak, Milan Timko, Arkadiusz Józefczak

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)
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There exist various types of hyperthermia therapy such as radiofrequency, infrared, microwave, focused ultrasound or magnetic. Recently, a lot of effort has been put into combining more than one mode of heating into one treatment. The multimodal hyperthermia proves a better alternative in comparison with a single one. In this paper, we show that the application of dual sono-magnetic heating (ultrasound and magnetic together) gives better results than using either of them alone. The advantage of this bimodal treatment lies not only in cumulative heating of target volume (tumor) but also in synergistic interaction between the two mechanisms—the ultrasound sonication can improve the thermal effect of magnetic hyperthermia through the unblocking Brown’s relaxation. Furthermore, the ultrasound and magnetic heating are complementary to each other. The temperature rise caused by ultrasound is fast changing and by magnetic field slow changing. So the parameters of ultrasound can serve as coarse-tuning settings of heating while the parameters of the magnetic field as fine-tuning enabling more precise hyperthermia.
Original languageEnglish
Article number166396
Number of pages6
JournalJournal of Magnetism and Magnetic Materials
Early online date3 Jan 2020
Publication statusPublished - 15 Apr 2020


  • sono-magnetic heating
  • magnetic nanoparticles
  • ultrasound
  • phantom


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