Solution co-crystallisation and its applications

Tom Leyssens, Joop H. ter Horst

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)


Even though the term co-crystal remains topic of debate, general consensus evolves towards defining co-crystals as crystalline compounds constructed of 2 or more neutral components which are, in their pure form, solid at room temperature and under atmospheric pressure. In most cases this definition clearly distinguishes co-crystals from salts or solvates. For solvates one of the components in its pure form, the solvent, is a liquid. A co-crystal is different from a salt since it is constructed from two distinct neutral components without any charge transfer taking place between components. Co-crystals can therefore be formed of components that lack ionizable functional groups.
Original languageEnglish
Title of host publicationMulti-Component Crystals
Subtitle of host publicationSynthesis, Concepts, Function
EditorsEdward R T Tiekink, Julio Zukerman-Schpector
Place of PublicationBerlin
PublisherWalter de Gruyter GmbH
Number of pages32
ISBN (Print)9783110463651
Publication statusPublished - 23 Nov 2017



  • co-crystals
  • salts
  • solvents
  • crystal solutions

Cite this

Leyssens, T., & ter Horst, J. H. (2017). Solution co-crystallisation and its applications. In E. R. T. Tiekink, & J. Zukerman-Schpector (Eds.), Multi-Component Crystals: Synthesis, Concepts, Function (pp. 205-236). Berlin: Walter de Gruyter GmbH.