Solution co-crystallisation and its applications

Even though the term co-crystal remains topic of debate, general consensus evolves towards defining co-crystals as crystalline compounds constructed of 2 or more neutral components which are, in their pure form, solid at room temperature and under atmospheric pressure. In most cases this definition clearly distinguishes co-crystals from salts or solvates. For solvates one of the components in its pure form, the solvent, is a liquid. A co-crystal is different from a salt since it is constructed from two distinct neutral components without any charge transfer taking place between components. Co-crystals can therefore be formed of components that lack ionizable functional groups.