Solubility measurement of poorly soluble drugs in fasted state simulated intestinal fluid

Zoe McKinnon; Hannah Batchelor; Ibrahim Khadra; Gavin Halbert

doi:10.5920/bjpharm.1075

Solubility measurement of poorly soluble drugs in fasted state simulated intestinal fluid

Zoe McKinnon, Hannah Batchelor, Ibrahim Khadra, Gavin Halbert

Strathclyde Institute Of Pharmacy And Biomedical Sciences

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Abstract

Adequatedrug solubility in the gastrointestinal tract is essential for systemic therapyof orally administered medications. To carry out research on the solubility ofpoorly soluble drugs in vitro, simulated intestinal fluid (SIF) is usedin place of human intestinal fluid (HIF). However, typical SIF reflects averagecompositions of HIF rather than the full range of compositions previouslyreported. This study examines a new suite of SIF media (based on variabilityobserved in HIF) to explore the range of solubility of four poorly soluble drugs(Naproxen, Indomethacin, Phenytoin and Tadalafil) in the fasted state.

Original language	English
Number of pages	2
Journal	British Journal of Pharmacy
Volume	7
Issue number	2
DOIs	https://doi.org/10.5920/bjpharm.1075
Publication status	Published - 2 Nov 2022

Keywords

gastrointestinal tract
drug solubility
simulated intestinal fluid

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10.5920/bjpharm.1075Licence: CC BY 4.0

McKinnon-etal-BJP-2022-Solubility-measurement-of-poorly-soluble-drugs-in-fasted-stateFinal published version, 345 KBLicence: CC BY 4.0

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abstract = "Adequatedrug solubility in the gastrointestinal tract is essential for systemic therapyof orally administered medications. To carry out research on the solubility ofpoorly soluble drugs in vitro, simulated intestinal fluid (SIF) is usedin place of human intestinal fluid (HIF). However, typical SIF reflects averagecompositions of HIF rather than the full range of compositions previouslyreported. This study examines a new suite of SIF media (based on variabilityobserved in HIF) to explore the range of solubility of four poorly soluble drugs(Naproxen, Indomethacin, Phenytoin and Tadalafil) in the fasted state.",

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T1 - Solubility measurement of poorly soluble drugs in fasted state simulated intestinal fluid

AU - McKinnon, Zoe

AU - Batchelor, Hannah

AU - Khadra, Ibrahim

AU - Halbert, Gavin

PY - 2022/11/2

Y1 - 2022/11/2

N2 - Adequatedrug solubility in the gastrointestinal tract is essential for systemic therapyof orally administered medications. To carry out research on the solubility ofpoorly soluble drugs in vitro, simulated intestinal fluid (SIF) is usedin place of human intestinal fluid (HIF). However, typical SIF reflects averagecompositions of HIF rather than the full range of compositions previouslyreported. This study examines a new suite of SIF media (based on variabilityobserved in HIF) to explore the range of solubility of four poorly soluble drugs(Naproxen, Indomethacin, Phenytoin and Tadalafil) in the fasted state.

AB - Adequatedrug solubility in the gastrointestinal tract is essential for systemic therapyof orally administered medications. To carry out research on the solubility ofpoorly soluble drugs in vitro, simulated intestinal fluid (SIF) is usedin place of human intestinal fluid (HIF). However, typical SIF reflects averagecompositions of HIF rather than the full range of compositions previouslyreported. This study examines a new suite of SIF media (based on variabilityobserved in HIF) to explore the range of solubility of four poorly soluble drugs(Naproxen, Indomethacin, Phenytoin and Tadalafil) in the fasted state.

KW - gastrointestinal tract

KW - drug solubility

KW - simulated intestinal fluid

U2 - 10.5920/bjpharm.1075

DO - 10.5920/bjpharm.1075

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Solubility measurement of poorly soluble drugs in fasted state simulated intestinal fluid

Abstract

Keywords

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