Research output: Chapter in Book/Report/Conference proceedingChapter


Solubility is a measurement of the amount of a substance that can stay in a solvent without precipitation. The solubility of a substance can change when pressure, temperature and/or the composition of the solvent changes thus it is important to accurately detail solubility data to provide sufficient information. Drug solubility within intestinal fluids can limit the overall absorption, as described in the maximum absorbable dose equation. Alternative polymorphic forms of a drug substance will have different crystalline forms which can affect their hydration and the time-frame to reach equilibrium solubility. Drug solubility in a range of solvents is of interest for both the prediction of biopharmaceutics parameters and also to aid in the formulation strategy. In biorelevant media, the bile salts and phospholipids form colloidal structures that include micelles that can enhance the measured solubility of the drug. Formulation solubilising vehicles including cosolvents, surfactants, complexation agents and oils/lipids are considered.

Original languageEnglish
Title of host publicationBiopharmaceutics
Subtitle of host publicationFrom Fundamentals to Industrial Practice
Place of PublicationChichester
Number of pages12
ISBN (Electronic)9781119678366
Publication statusPublished - 28 Jan 2022


  • biopharmaceutics parameters
  • biorelevant media
  • drug absorption
  • drus solubility
  • solvents


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