Solid-to-solid biocatalysis: thermodynamic feasibility and energy efficiency

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Enzymes can catalyse solid-to-solid condensation reactions in highly concentrated aqueous substrate suspensions. Reaction products precipitate from the reaction mixture and very high conversion yields can be obtained in low volume reactors. Solid-to-solid biocatalysis combines the advantages of using enzymes in aqueous media with the high conversion yields that are typically associated with non-aqueous biocatalysis. In this article, methods are presented for the calculation of the Gibbs free energy changes and heats of reaction of condensation reactions to form amides. The overall enthalpy change of the enzymatic reaction was compared to that of the conventional chemical methods and it was found that the enzymatic reaction produces a third of the heat with better atom efficiency.
LanguageEnglish
Pages488-496
Number of pages8
JournalGreen Chemistry
Volume6
Issue number9
DOIs
Publication statusPublished - 2004

Fingerprint

energy efficiency
Energy efficiency
thermodynamics
Thermodynamics
Condensation reactions
condensation
Enzymes
enzyme
Gibbs free energy
chemical method
Reaction products
enthalpy
Amides
Precipitates
Enthalpy
Suspensions
substrate
Atoms
Biocatalysis
Substrates

Keywords

  • solid-to-solid condensation reactions
  • biocatalysis
  • non-aqueous biocatalysis
  • enthalpy change
  • enzymatic reaction

Cite this

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Solid-to-solid biocatalysis: thermodynamic feasibility and energy efficiency. / Ulijn, R.V.; Halling, P.J.

In: Green Chemistry, Vol. 6, No. 9, 2004, p. 488-496.

Research output: Contribution to journalArticle

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T1 - Solid-to-solid biocatalysis: thermodynamic feasibility and energy efficiency

AU - Ulijn, R.V.

AU - Halling, P.J.

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AB - Enzymes can catalyse solid-to-solid condensation reactions in highly concentrated aqueous substrate suspensions. Reaction products precipitate from the reaction mixture and very high conversion yields can be obtained in low volume reactors. Solid-to-solid biocatalysis combines the advantages of using enzymes in aqueous media with the high conversion yields that are typically associated with non-aqueous biocatalysis. In this article, methods are presented for the calculation of the Gibbs free energy changes and heats of reaction of condensation reactions to form amides. The overall enthalpy change of the enzymatic reaction was compared to that of the conventional chemical methods and it was found that the enzymatic reaction produces a third of the heat with better atom efficiency.

KW - solid-to-solid condensation reactions

KW - biocatalysis

KW - non-aqueous biocatalysis

KW - enthalpy change

KW - enzymatic reaction

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