Solid-to-solid biocatalysis: thermodynamic feasibility and energy efficiency

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Enzymes can catalyse solid-to-solid condensation reactions in highly concentrated aqueous substrate suspensions. Reaction products precipitate from the reaction mixture and very high conversion yields can be obtained in low volume reactors. Solid-to-solid biocatalysis combines the advantages of using enzymes in aqueous media with the high conversion yields that are typically associated with non-aqueous biocatalysis. In this article, methods are presented for the calculation of the Gibbs free energy changes and heats of reaction of condensation reactions to form amides. The overall enthalpy change of the enzymatic reaction was compared to that of the conventional chemical methods and it was found that the enzymatic reaction produces a third of the heat with better atom efficiency.
Original languageEnglish
Pages (from-to)488-496
Number of pages8
JournalGreen Chemistry
Issue number9
Publication statusPublished - 2004


  • solid-to-solid condensation reactions
  • biocatalysis
  • non-aqueous biocatalysis
  • enthalpy change
  • enzymatic reaction


Dive into the research topics of 'Solid-to-solid biocatalysis: thermodynamic feasibility and energy efficiency'. Together they form a unique fingerprint.

Cite this