A library of thiazolidinedione-fatty acid hybrid mols. was designed to probe the relationship between natural and synthetic PPAR ligands. Solid-phase synthesis of the library led to the identification of several high affinity PPARγ ligands.
- hybrid thiazolidinedione
- fatty acid PPARγ ligand
- solid-phase synthesis
- organic chemistry
Tomkinson, N. C. O., Sefler, A. M., Plunket, K. D., Blanchard, S. G., Parks, D. J., & Willson, T. M. (1997). Solid-phase synthesis of hybrid thiazolidinedione-fatty acid PPARγ ligands. Bioorganic and Medicinal Chemistry Letters, 7(19), 2491-2496. https://doi.org/10.1016/S0960-894X(97)10017-8