Solid-phase synthesis of hybrid thiazolidinedione-fatty acid PPARγ ligands.

Nicholas C. O. Tomkinson; Andrea M. Sefler; Kelli D. Plunket; Steven G. Blanchard; Derek J. Parks; Timothy M. Willson

doi:10.1016/S0960-894X(97)10017-8

Solid-phase synthesis of hybrid thiazolidinedione-fatty acid PPARγ ligands.

Nicholas C. O. Tomkinson, Andrea M. Sefler, Kelli D. Plunket, Steven G. Blanchard, Derek J. Parks, Timothy M. Willson

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

A library of thiazolidinedione-fatty acid hybrid mols. was designed to probe the relationship between natural and synthetic PPAR ligands. Solid-phase synthesis of the library led to the identification of several high affinity PPARγ ligands.

Original language	Undefined/Unknown
Pages (from-to)	2491-2496
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	19
DOIs	https://doi.org/10.1016/S0960-894X(97)10017-8
Publication status	Published - 1997

Keywords

hybrid thiazolidinedione
fatty acid PPARγ ligand
solid-phase synthesis
organic chemistry
ligands

Access to Document

10.1016/S0960-894X(97)10017-8

Cite this

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title = "Solid-phase synthesis of hybrid thiazolidinedione-fatty acid PPARγ ligands.",

abstract = "A library of thiazolidinedione-fatty acid hybrid mols. was designed to probe the relationship between natural and synthetic PPAR ligands. Solid-phase synthesis of the library led to the identification of several high affinity PPARγ ligands. ",

keywords = "hybrid thiazolidinedione , fatty acid PPARγ ligand , solid-phase synthesis, organic chemistry, ligands",

author = "Tomkinson, {Nicholas C. O.} and Sefler, {Andrea M.} and Plunket, {Kelli D.} and Blanchard, {Steven G.} and Parks, {Derek J.} and Willson, {Timothy M.}",

year = "1997",

doi = "10.1016/S0960-894X(97)10017-8",

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volume = "7",

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journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

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T1 - Solid-phase synthesis of hybrid thiazolidinedione-fatty acid PPARγ ligands.

AU - Tomkinson, Nicholas C. O.

AU - Sefler, Andrea M.

AU - Plunket, Kelli D.

AU - Blanchard, Steven G.

AU - Parks, Derek J.

AU - Willson, Timothy M.

PY - 1997

Y1 - 1997

N2 - A library of thiazolidinedione-fatty acid hybrid mols. was designed to probe the relationship between natural and synthetic PPAR ligands. Solid-phase synthesis of the library led to the identification of several high affinity PPARγ ligands.

AB - A library of thiazolidinedione-fatty acid hybrid mols. was designed to probe the relationship between natural and synthetic PPAR ligands. Solid-phase synthesis of the library led to the identification of several high affinity PPARγ ligands.

KW - hybrid thiazolidinedione

KW - fatty acid PPARγ ligand

KW - solid-phase synthesis

KW - organic chemistry

KW - ligands

U2 - 10.1016/S0960-894X(97)10017-8

DO - 10.1016/S0960-894X(97)10017-8

M3 - Article

SN - 0960-894X

VL - 7

SP - 2491

EP - 2496

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 19

ER -