Solid-phase synthesis of hybrid thiazolidinedione-fatty acid PPARγ ligands.

Nicholas C. O. Tomkinson, Andrea M. Sefler, Kelli D. Plunket, Steven G. Blanchard, Derek J. Parks, Timothy M. Willson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A library of thiazolidinedione-fatty acid hybrid mols. was designed to probe the relationship between natural and synthetic PPAR ligands. Solid-phase synthesis of the library led to the identification of several high affinity PPARγ ligands.
Original languageUndefined/Unknown
Pages (from-to)2491-2496
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number19
DOIs
Publication statusPublished - 1997

Keywords

  • hybrid thiazolidinedione
  • fatty acid PPARγ ligand
  • solid-phase synthesis
  • organic chemistry
  • ligands

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