Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery

B. Newland, C. Taplan, D. Pette, J. Friedrichs, M. Steinhart, W. Wang, B. Voit, F.P. Seib, C. Werner

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nanotubes are emerging as promising materials for healthcare applications but the selection of clinically relevant starting materials for their synthesis remains largely unexplored. Here we present, for the first time, the synthesis of poly(ethylene glycol) (PEG) based nanotubes via the photopolymerization of poly(ethylene glycol) diacrylate and other diacrylate derivatives within the pores of anodized aluminum oxide templates. Template-assisted synthesis allowed the manufacture of a diverse set of polymeric nanotubes with tunable physical characteristics including diameter (∼200–400 nm) and stiffness (405–902 kPa). PEG nanotubes were subjected to cytotoxicty assessment in cell lines and primary stem cells and showed excellent cytocompatability (IC50 > 120 μg ml−1). Nanotubes were readily drug loaded but released the majority of the drug over 5 days. Direct administration of drug loaded nanotubes to human orthotopic breast tumors substantially reduced tumor growth and metastasis and outperformed i.v. administration at the equivalent dose. Overall, this nanotube templating platform is emerging as a facile route for the manufacture of poly(ethylene glycol) nanotubes.
LanguageEnglish
Pages8413-8421
Number of pages9
JournalNanoscale
Volume10
Issue number18
DOIs
Publication statusPublished - 1 May 2018

Fingerprint

Nanotubes
Ethylene Glycol
Drug delivery
Polyethylene glycols
Pharmaceutical Preparations
Tumors
Photopolymerization
Aluminum Oxide
Stem cells
Inhibitory Concentration 50
Stem Cells
Cells
Stiffness
Breast Neoplasms
Neoplasm Metastasis
Derivatives
Delivery of Health Care
Aluminum
Cell Line
Oxides

Keywords

  • stem cells
  • nanotubes
  • poly(ethylene glycol)
  • drug delivery

Cite this

Newland, B., Taplan, C., Pette, D., Friedrichs, J., Steinhart, M., Wang, W., ... Werner, C. (2018). Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery. Nanoscale, 10(18), 8413-8421. https://doi.org/10.1039/C8NR00603B
Newland, B. ; Taplan, C. ; Pette, D. ; Friedrichs, J. ; Steinhart, M. ; Wang, W. ; Voit, B. ; Seib, F.P. ; Werner, C. / Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery. In: Nanoscale. 2018 ; Vol. 10, No. 18. pp. 8413-8421.
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Newland, B, Taplan, C, Pette, D, Friedrichs, J, Steinhart, M, Wang, W, Voit, B, Seib, FP & Werner, C 2018, 'Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery' Nanoscale, vol. 10, no. 18, pp. 8413-8421. https://doi.org/10.1039/C8NR00603B

Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery. / Newland, B.; Taplan, C.; Pette, D.; Friedrichs, J.; Steinhart, M.; Wang, W.; Voit, B.; Seib, F.P.; Werner, C.

In: Nanoscale, Vol. 10, No. 18, 01.05.2018, p. 8413-8421.

Research output: Contribution to journalArticle

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Newland B, Taplan C, Pette D, Friedrichs J, Steinhart M, Wang W et al. Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery. Nanoscale. 2018 May 1;10(18):8413-8421. https://doi.org/10.1039/C8NR00603B