Socioeconomic deprivation and cortical morphology: psychological, social, and biological determinants of ill health study

Rajeev Krishnadas, John Mclean, G. David Batty, Harry Burns, Kevin A. Deans, Ian Ford, Alex Mcconnachie, Jennifer S. Mclean, Keith Millar, Naveed Sattar, Paul G. Shiels, Carol Tannahill, Yoga N. Velupillai, Chris J. Packard, Jonathan Cavanagh

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

OBJECTIVE: Neighborhood-level socioeconomic deprivation has been associated with poor cognitive function pertaining to language and the executive control. Few studies have explored the cortical morphology of regions most commonly associated with these functions. The aim of this study was to examine the association between neighborhood-level deprivation and the morphology of cortical regions associated with language and executive control in adults. METHODS: Using a cross-sectional study design, we compared the cortical morphology of 42 neurologically healthy adult men from the least deprived and most deprived neighborhoods of Glasgow. We performed surface-based morphometry on 3-T structural magnetic resonance imaging (MRI) images to extract the cortical morphology - volume, thickness (CT), and surface area (SA) of regions commonly associated with language and executive control. Cortical morphology was compared between the two groups. We used mediation analysis to examine whether cardiometabolic risk factors mediated the relationship between deprivation status and cortical morphology. RESULTS: Intracranial volume and mean total CT did not differ between groups. The deprived group had significantly smaller left posterior parietal cortex SA (Cohen d = 0.89) and fusiform cortex SA (Cohen d = 1.05). They also had thinner left Wernicke's area (Cohen d =0.93) and its right homologue (Cohen d = 1.12). Among the cardiometabolic markers, a composite factor comprising inflammatory markers mediated the relationship between deprivation status and Wernicke's area CT. CONCLUSIONS: A group of neurologically healthy men from deprived neighborhoods showed significantly smaller cortical morphology - both SA and CT - in regions of the brain pertaining to language and executive function. We provide additional evidence of a relationship between socioeconomic deprivation and cortical morphology.

LanguageEnglish
Pages616-623
Number of pages8
JournalPsychosomatic Medicine
Volume75
Issue number7
DOIs
Publication statusPublished - 1 Jan 2013
Externally publishedYes

Fingerprint

Executive Function
Language
Psychology
Health
Parietal Lobe
Cone-Beam Computed Tomography
Cognition
Cross-Sectional Studies
Magnetic Resonance Imaging
Brain
Wernicke Area

Keywords

  • cardiometabolic risk
  • deprivation
  • executive control
  • inflammation
  • language
  • socioeconomic status

Cite this

Krishnadas, Rajeev ; Mclean, John ; Batty, G. David ; Burns, Harry ; Deans, Kevin A. ; Ford, Ian ; Mcconnachie, Alex ; Mclean, Jennifer S. ; Millar, Keith ; Sattar, Naveed ; Shiels, Paul G. ; Tannahill, Carol ; Velupillai, Yoga N. ; Packard, Chris J. ; Cavanagh, Jonathan. / Socioeconomic deprivation and cortical morphology : psychological, social, and biological determinants of ill health study. In: Psychosomatic Medicine. 2013 ; Vol. 75, No. 7. pp. 616-623.
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abstract = "OBJECTIVE: Neighborhood-level socioeconomic deprivation has been associated with poor cognitive function pertaining to language and the executive control. Few studies have explored the cortical morphology of regions most commonly associated with these functions. The aim of this study was to examine the association between neighborhood-level deprivation and the morphology of cortical regions associated with language and executive control in adults. METHODS: Using a cross-sectional study design, we compared the cortical morphology of 42 neurologically healthy adult men from the least deprived and most deprived neighborhoods of Glasgow. We performed surface-based morphometry on 3-T structural magnetic resonance imaging (MRI) images to extract the cortical morphology - volume, thickness (CT), and surface area (SA) of regions commonly associated with language and executive control. Cortical morphology was compared between the two groups. We used mediation analysis to examine whether cardiometabolic risk factors mediated the relationship between deprivation status and cortical morphology. RESULTS: Intracranial volume and mean total CT did not differ between groups. The deprived group had significantly smaller left posterior parietal cortex SA (Cohen d = 0.89) and fusiform cortex SA (Cohen d = 1.05). They also had thinner left Wernicke's area (Cohen d =0.93) and its right homologue (Cohen d = 1.12). Among the cardiometabolic markers, a composite factor comprising inflammatory markers mediated the relationship between deprivation status and Wernicke's area CT. CONCLUSIONS: A group of neurologically healthy men from deprived neighborhoods showed significantly smaller cortical morphology - both SA and CT - in regions of the brain pertaining to language and executive function. We provide additional evidence of a relationship between socioeconomic deprivation and cortical morphology.",
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Krishnadas, R, Mclean, J, Batty, GD, Burns, H, Deans, KA, Ford, I, Mcconnachie, A, Mclean, JS, Millar, K, Sattar, N, Shiels, PG, Tannahill, C, Velupillai, YN, Packard, CJ & Cavanagh, J 2013, 'Socioeconomic deprivation and cortical morphology: psychological, social, and biological determinants of ill health study' Psychosomatic Medicine, vol. 75, no. 7, pp. 616-623. https://doi.org/10.1097/PSY.0b013e3182a151a7

Socioeconomic deprivation and cortical morphology : psychological, social, and biological determinants of ill health study. / Krishnadas, Rajeev; Mclean, John; Batty, G. David; Burns, Harry; Deans, Kevin A.; Ford, Ian; Mcconnachie, Alex; Mclean, Jennifer S.; Millar, Keith; Sattar, Naveed; Shiels, Paul G.; Tannahill, Carol; Velupillai, Yoga N.; Packard, Chris J.; Cavanagh, Jonathan.

In: Psychosomatic Medicine, Vol. 75, No. 7, 01.01.2013, p. 616-623.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Socioeconomic deprivation and cortical morphology

T2 - Psychosomatic Medicine

AU - Krishnadas, Rajeev

AU - Mclean, John

AU - Batty, G. David

AU - Burns, Harry

AU - Deans, Kevin A.

AU - Ford, Ian

AU - Mcconnachie, Alex

AU - Mclean, Jennifer S.

AU - Millar, Keith

AU - Sattar, Naveed

AU - Shiels, Paul G.

AU - Tannahill, Carol

AU - Velupillai, Yoga N.

AU - Packard, Chris J.

AU - Cavanagh, Jonathan

PY - 2013/1/1

Y1 - 2013/1/1

N2 - OBJECTIVE: Neighborhood-level socioeconomic deprivation has been associated with poor cognitive function pertaining to language and the executive control. Few studies have explored the cortical morphology of regions most commonly associated with these functions. The aim of this study was to examine the association between neighborhood-level deprivation and the morphology of cortical regions associated with language and executive control in adults. METHODS: Using a cross-sectional study design, we compared the cortical morphology of 42 neurologically healthy adult men from the least deprived and most deprived neighborhoods of Glasgow. We performed surface-based morphometry on 3-T structural magnetic resonance imaging (MRI) images to extract the cortical morphology - volume, thickness (CT), and surface area (SA) of regions commonly associated with language and executive control. Cortical morphology was compared between the two groups. We used mediation analysis to examine whether cardiometabolic risk factors mediated the relationship between deprivation status and cortical morphology. RESULTS: Intracranial volume and mean total CT did not differ between groups. The deprived group had significantly smaller left posterior parietal cortex SA (Cohen d = 0.89) and fusiform cortex SA (Cohen d = 1.05). They also had thinner left Wernicke's area (Cohen d =0.93) and its right homologue (Cohen d = 1.12). Among the cardiometabolic markers, a composite factor comprising inflammatory markers mediated the relationship between deprivation status and Wernicke's area CT. CONCLUSIONS: A group of neurologically healthy men from deprived neighborhoods showed significantly smaller cortical morphology - both SA and CT - in regions of the brain pertaining to language and executive function. We provide additional evidence of a relationship between socioeconomic deprivation and cortical morphology.

AB - OBJECTIVE: Neighborhood-level socioeconomic deprivation has been associated with poor cognitive function pertaining to language and the executive control. Few studies have explored the cortical morphology of regions most commonly associated with these functions. The aim of this study was to examine the association between neighborhood-level deprivation and the morphology of cortical regions associated with language and executive control in adults. METHODS: Using a cross-sectional study design, we compared the cortical morphology of 42 neurologically healthy adult men from the least deprived and most deprived neighborhoods of Glasgow. We performed surface-based morphometry on 3-T structural magnetic resonance imaging (MRI) images to extract the cortical morphology - volume, thickness (CT), and surface area (SA) of regions commonly associated with language and executive control. Cortical morphology was compared between the two groups. We used mediation analysis to examine whether cardiometabolic risk factors mediated the relationship between deprivation status and cortical morphology. RESULTS: Intracranial volume and mean total CT did not differ between groups. The deprived group had significantly smaller left posterior parietal cortex SA (Cohen d = 0.89) and fusiform cortex SA (Cohen d = 1.05). They also had thinner left Wernicke's area (Cohen d =0.93) and its right homologue (Cohen d = 1.12). Among the cardiometabolic markers, a composite factor comprising inflammatory markers mediated the relationship between deprivation status and Wernicke's area CT. CONCLUSIONS: A group of neurologically healthy men from deprived neighborhoods showed significantly smaller cortical morphology - both SA and CT - in regions of the brain pertaining to language and executive function. We provide additional evidence of a relationship between socioeconomic deprivation and cortical morphology.

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KW - deprivation

KW - executive control

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