SNARE Proteins Underpin Insulin-Regulated GLUT4 Traffic

Nia J. Bryant, Gwyn W. Gould

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Delivery of the glucose transporter type 4 (GLUT4) from an intracellular location to the cell surface in response to insulin represents a specialized form of membrane traffic, known to be impaired in the disease states of insulin resistance and type 2 diabetes. Like all membrane trafficking events, this translocation of GLUT4 requires members of the SNARE family of proteins. Here, we discuss two SNARE complexes that have been implicated in insulin-regulated GLUT4 traffic: one regulating the final delivery of GLUT4 to the cell surface in response to insulin and the other controlling GLUT4's intracellular trafficking.

Original languageEnglish
Pages (from-to)657-664
Number of pages8
JournalTraffic
Volume12
Issue number6
Early online date8 Feb 2011
DOIs
Publication statusPublished - 30 Jun 2011

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Keywords

  • GLUT4
  • Insulin
  • Sec1/Munc18
  • SNAREs
  • Syntaxin

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