SNARE phosphorylation: a control mechanism for insulin-stimulated glucose transport and other regulated exocytic events

Kamilla M.E. Laidlaw, Rachel Livingstone, Mohammed Al-Tobi, Nia J. Bryant, Gwyn W. Gould

Research output: Contribution to journalReview article

6 Citations (Scopus)
13 Downloads (Pure)

Abstract

Trafficking within eukaryotic cells is a complex and highly regulated process; events such as recycling of plasma membrane receptors, formation of multivesicular bodies, regulated release of hormones and delivery of proteins to membranes all require directionality and specificity. The underpinning processes, including cargo selection, membrane fusion, trafficking flow and timing, are controlled by a variety of molecular mechanisms and engage multiple families of lipids and proteins. Here, we will focus on control of trafficking processes via the action of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family of proteins, in particular their regulation by phosphorylation. We will describe how these proteins are controlled in a range of regulated trafficking events, with particular emphasis on the insulin-stimulated delivery of glucose transporters to the surface of adipose and muscle cells. Here, we focus on a few examples of SNARE phosphorylation which exemplify distinct ways in which SNARE machinery phosphorylation may regulate membrane fusion.

Original languageEnglish
Pages (from-to)1271-1277
Number of pages7
JournalBiochemical Society Transactions
Volume45
Issue number6
DOIs
Publication statusPublished - 15 Dec 2017

Keywords

  • glucose transport
  • SNARE
  • phosphorylation
  • insulin
  • cell membranes

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