Snake peptides

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Snake venoms are complex mixtures of small molecules, peptides, and proteins. Most of the biologically active toxins are peptides or enzymes. This chapter covers the nonenzymatically active peptides and toxins. The peptides belong to several structural classes, and they have many different biological actions. The best characterized peptides are the so-called three-finger toxins that have 60–70 amino acid residues in three peptide loops stabilized by four disulfide bridges. Despite their common 3D shape, these peptides can interfere selectively with different biological targets, including nicotinic and muscarinic acetylcholine receptors, acetylcholinesterase, ion channels, and cell membranes. Other small peptides can block K+ or Ca2+ channels and are based on Kunitz serine proteinase inhibitors (~60 amino acid residues and three disulfide bonds), whereas other toxins have different molecular scaffolds and different pharmacological activities. Many snake venom peptides are useful pharmacological tools, whereas others are leads for drug development.
Original languageEnglish
Title of host publicationHandbook of Biologically Active Peptides
EditorsAbba Kastin
Pages451-460
Number of pages10
DOIs
Publication statusPublished - 1 Jan 2013

Keywords

  • snake peptides
  • biologically active peptides
  • snake venoms
  • nonenzymatically active peptides
  • toxins

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  • Cite this

    Harvey, A. L. (2013). Snake peptides. In A. Kastin (Ed.), Handbook of Biologically Active Peptides (pp. 451-460) https://doi.org/10.1016/B978-0-12-385095-9.00062-2