Smart wide-field fluorescence lifetime imaging system with CMOS single-photon avalanche diode arrays

Dong Xiao, Zhenya Zang, Quan Wang, Ziao Jiao, Francescopaolo Mattioli Della Rocca, Yu Chen, David Day Uei Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

2 Citations (Scopus)
34 Downloads (Pure)

Abstract

Wide-field fluorescence lifetime imaging (FLIM) is a promising technique for biomedical and clinic applications. Integrating with CMOS single-photon avalanche diode (SPAD) sensor arrays can lead to cheaper and portable real-time FLIM systems. However, the FLIM data obtained by such sensor systems often have sophisticated noise features. There is still a lack of fast tools to recover lifetime parameters from highly noise-corrupted fluorescence signals efficiently. This paper proposes a smart wide-field FLIM system containing a 192×128 COMS SPAD sensor and a field-programmable gate array (FPGA) embedded deep learning (DL) FLIM processor. The processor adopts a hardware-friendly and light-weighted neural network for fluorescence lifetime analysis, showing the advantages of high accuracy against noise, fast speed, and low power consumption. Experimental results demonstrate the proposed system's superior and robust performances, promising for many FLIM applications such as FLIM-guided clinical surgeries, cancer diagnosis, and biomedical imaging
Original languageEnglish
Title of host publication2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Place of PublicationPiscataway, NJ
PublisherIEEE
Pages1887-1890
Number of pages4
Volume2022
ISBN (Electronic)9781728127828
ISBN (Print)9781728127835
DOIs
Publication statusPublished - 8 Sept 2022
Event44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'22) - Scottish Event Campus (SEC) , Glasgow, United Kingdom
Duration: 11 Jul 202215 Jul 2022
https://embc.embs.org/2022/#:~:text=About%20the%20Conference&text=The%20IEEE%20Engineering%20in%20Medicine,from%2011%2D15%20July%202022.

Conference

Conference44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'22)
Country/TerritoryUnited Kingdom
CityGlasgow
Period11/07/2215/07/22
Internet address

Keywords

  • array signal processing
  • neural networks
  • surgery
  • fluorescence
  • sensor systems
  • field programmable gate arrays (FPGA)
  • single-photon avalanche diodes

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