Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

Justyna Rzepecka; Michelle Coates; Moninder Saggar; Lamyaa Al-Riyami; Jennifer Coltherd; Hwee Kee Tay; Judith Huggan; Lucia Janicova; Abedawn Khalaf; Ivonne Siebeke; Colin Suckling; Margaret Harnett; William Harnett

doi:10.1016/j.ijpara.2014.05.001

Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

Justyna Rzepecka, Michelle Coates, Moninder Saggar, Lamyaa Al-Riyami, Jennifer Coltherd, Hwee Kee Tay, Judith Huggan, Lucia Janicova, Abedawn Khalaf, Ivonne Siebeke, Colin Suckling, Margaret Harnett, William Harnett

Research output: Contribution to journal › Article › peer-review

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Abstract

ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, exhibits anti-inflamma-tory properties by virtue of covalently attached phosphorylcholine moieties. Screening of a library of ES-62 phosphorylcholine-based small molecule analogues (SMAs) revealed that two compounds, termed 11a and 12b, mirrored the helminth product both in inhibiting mast cell degranulation and cytokine responses in vitro and in preventing ovalbumin-induced Th2-associated airway inflammation and eosin- ophil infiltration of the lungs in mice. Furthermore, the two SMAs inhibited neutrophil infiltration of the
lungs when administered therapeutically. ES-62-SMAs 11a and 12b thus represent starting points for novel drug development for allergies such as asthma.

Original language	English
Pages (from-to)	669-674
Number of pages	6
Journal	International Journal for Parasitology
Volume	44
Issue number	9
Early online date	12 Jun 2014
DOIs	https://doi.org/10.1016/j.ijpara.2014.05.001
Publication status	Published - Aug 2014

Keywords

asthma
ES-62
parasitic helminth
immunomodulation
phosphorylcholine
Acanthocheilonema viteae

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijpara.2014.05.001

Rzepecka-etal-IJP2014-immunomodulatory-parasitic-helminth-product-es-62-aamAccepted author manuscript, 461 KB

Cite this

Rzepecka, J., Coates, M., Saggar, M., Al-Riyami, L., Coltherd, J., Tay, H. K., Huggan, J., Janicova, L., Khalaf, A., Siebeke, I., Suckling, C., Harnett, M., & Harnett, W. (2014). Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties. International Journal for Parasitology, 44(9), 669-674. https://doi.org/10.1016/j.ijpara.2014.05.001

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title = "Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties",

abstract = "ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, exhibits anti-inflamma-tory properties by virtue of covalently attached phosphorylcholine moieties. Screening of a library of ES-62 phosphorylcholine-based small molecule analogues (SMAs) revealed that two compounds, termed 11a and 12b, mirrored the helminth product both in inhibiting mast cell degranulation and cytokine responses in vitro and in preventing ovalbumin-induced Th2-associated airway inflammation and eosin- ophil infiltration of the lungs in mice. Furthermore, the two SMAs inhibited neutrophil infiltration of the lungs when administered therapeutically. ES-62-SMAs 11a and 12b thus represent starting points for novel drug development for allergies such as asthma.",

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author = "Justyna Rzepecka and Michelle Coates and Moninder Saggar and Lamyaa Al-Riyami and Jennifer Coltherd and Tay, {Hwee Kee} and Judith Huggan and Lucia Janicova and Abedawn Khalaf and Ivonne Siebeke and Colin Suckling and Margaret Harnett and William Harnett",

note = ". Notice: This is the author's version of a work that was accepted for publication in International Journal for Parasitology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal for Parasitology, [44, 9, (August 2014)] DOI: 10.1016/j.ijpara.2014.05.001.",

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Rzepecka, J, Coates, M, Saggar, M, Al-Riyami, L, Coltherd, J, Tay, HK, Huggan, J, Janicova, L, Khalaf, A, Siebeke, I, Suckling, C, Harnett, M & Harnett, W 2014, 'Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties', International Journal for Parasitology, vol. 44, no. 9, pp. 669-674. https://doi.org/10.1016/j.ijpara.2014.05.001

TY - JOUR

T1 - Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

AU - Rzepecka, Justyna

AU - Coates, Michelle

AU - Saggar, Moninder

AU - Al-Riyami, Lamyaa

AU - Coltherd, Jennifer

AU - Tay, Hwee Kee

AU - Huggan, Judith

AU - Janicova, Lucia

AU - Khalaf, Abedawn

AU - Siebeke, Ivonne

AU - Suckling, Colin

AU - Harnett, Margaret

AU - Harnett, William

N1 - . Notice: This is the author's version of a work that was accepted for publication in International Journal for Parasitology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal for Parasitology, [44, 9, (August 2014)] DOI: 10.1016/j.ijpara.2014.05.001.

PY - 2014/8

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N2 - ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, exhibits anti-inflamma-tory properties by virtue of covalently attached phosphorylcholine moieties. Screening of a library of ES-62 phosphorylcholine-based small molecule analogues (SMAs) revealed that two compounds, termed 11a and 12b, mirrored the helminth product both in inhibiting mast cell degranulation and cytokine responses in vitro and in preventing ovalbumin-induced Th2-associated airway inflammation and eosin- ophil infiltration of the lungs in mice. Furthermore, the two SMAs inhibited neutrophil infiltration of the lungs when administered therapeutically. ES-62-SMAs 11a and 12b thus represent starting points for novel drug development for allergies such as asthma.

AB - ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, exhibits anti-inflamma-tory properties by virtue of covalently attached phosphorylcholine moieties. Screening of a library of ES-62 phosphorylcholine-based small molecule analogues (SMAs) revealed that two compounds, termed 11a and 12b, mirrored the helminth product both in inhibiting mast cell degranulation and cytokine responses in vitro and in preventing ovalbumin-induced Th2-associated airway inflammation and eosin- ophil infiltration of the lungs in mice. Furthermore, the two SMAs inhibited neutrophil infiltration of the lungs when administered therapeutically. ES-62-SMAs 11a and 12b thus represent starting points for novel drug development for allergies such as asthma.

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KW - immunomodulation

KW - phosphorylcholine

KW - Acanthocheilonema viteae

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DO - 10.1016/j.ijpara.2014.05.001

M3 - Article

SN - 0020-7519

VL - 44

SP - 669

EP - 674

JO - International Journal for Parasitology

JF - International Journal for Parasitology

IS - 9

ER -

Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

Abstract

Keywords

UN SDGs

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William Harnett

SMALL MOLECULE ANALOGUES (SMA'S) OF AN IMMUNOMDULATORY HELMINTH PRODUCT PROVIDE A NOVEL APPROACH TO DISSECTING MACROPHAGE SIGNAL TRANDUCTION PATHWAYS

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Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

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William Harnett

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SMALL MOLECULE ANALOGUES (SMA'S) OF AN IMMUNOMDULATORY HELMINTH PRODUCT PROVIDE A NOVEL APPROACH TO DISSECTING MACROPHAGE SIGNAL TRANDUCTION PATHWAYS

Cite this