Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy

Yuan Yan Sin, Tamara P Martin, Lauren Wills, Susan Currie, George S Baillie

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Nuclear import of protein kinase D1 (PKD1) is an important event in the transcriptional regulation of cardiac gene reprogramming leading to the hypertrophic growth response, however, little is known about the molecular events that govern this event. We have identified a novel complex between PKD1 and a heat shock protein (Hsp), Hsp20, which has been implicated as cardioprotective. This study aims to characterize the role of the complex in PKD1-mediated myocardial regulatory mechanisms that depend on PKD1 nuclear translocation.
LanguageEnglish
Article number16
Number of pages11
JournalCell Communication and Signalling
Volume13
DOIs
Publication statusPublished - 7 Mar 2015

Fingerprint

HSP20 Heat-Shock Proteins
Small Heat-Shock Proteins
Cell Nucleus Active Transport
Cardiomegaly
Nuclear Proteins
Heat-Shock Proteins
Protein Kinases
Genes
Growth
protein kinase D

Keywords

  • Hsp20
  • PKD1
  • cardiac hypertrophy
  • peptide array

Cite this

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title = "Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy",
abstract = "Nuclear import of protein kinase D1 (PKD1) is an important event in the transcriptional regulation of cardiac gene reprogramming leading to the hypertrophic growth response, however, little is known about the molecular events that govern this event. We have identified a novel complex between PKD1 and a heat shock protein (Hsp), Hsp20, which has been implicated as cardioprotective. This study aims to characterize the role of the complex in PKD1-mediated myocardial regulatory mechanisms that depend on PKD1 nuclear translocation.",
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Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy. / Sin, Yuan Yan; Martin, Tamara P; Wills, Lauren; Currie, Susan; Baillie, George S.

In: Cell Communication and Signalling, Vol. 13, 16, 07.03.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy

AU - Sin, Yuan Yan

AU - Martin, Tamara P

AU - Wills, Lauren

AU - Currie, Susan

AU - Baillie, George S

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KW - Hsp20

KW - PKD1

KW - cardiac hypertrophy

KW - peptide array

UR - http://www.biosignaling.com/

U2 - 10.1186/s12964-015-0094-x

DO - 10.1186/s12964-015-0094-x

M3 - Article

VL - 13

JO - Cell Communication and Signalling

T2 - Cell Communication and Signalling

JF - Cell Communication and Signalling

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