Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy

Yuan Yan Sin, Tamara P Martin, Lauren Wills, Susan Currie, George S Baillie

Research output: Contribution to journalArticle

12 Citations (Scopus)
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Abstract

Nuclear import of protein kinase D1 (PKD1) is an important event in the transcriptional regulation of cardiac gene reprogramming leading to the hypertrophic growth response, however, little is known about the molecular events that govern this event. We have identified a novel complex between PKD1 and a heat shock protein (Hsp), Hsp20, which has been implicated as cardioprotective. This study aims to characterize the role of the complex in PKD1-mediated myocardial regulatory mechanisms that depend on PKD1 nuclear translocation.
Original languageEnglish
Article number16
Number of pages11
JournalCell Communication and Signalling
Volume13
DOIs
Publication statusPublished - 7 Mar 2015

Keywords

  • Hsp20
  • PKD1
  • cardiac hypertrophy
  • peptide array

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