Sleep problems in cancer patients: prevalence and association with distress and pain

Neelom Sharma, Christian Holm Hansen, Mark O'Connor, Parvez Thekkumpurath, Jane Walker, Annet Kleiboer, Colin Espie, Dawn Storey, Michael Sharpe, Leanne Fleming

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52 Citations (Scopus)

Abstract

BACKGROUND: Although it is increasingly recognized that cancer patients often have sleep problems, we lack data on their prevalence and associations in representative clinical populations. We aimed to determine (i) the prevalence of sleep problems amongst outpatients of a cancer centre and (ii) the association with medical variables, emotional distress and pain.

METHODS: Secondary analysis of self-report and medical data on 2862 cancer centre outpatients. Sleep problems were identified using the sleep item from the Patient Health Questionnaire-9: 'Over the last two weeks, how often have you been bothered by trouble falling or staying asleep or sleeping too much?' scored on a four-point frequency scale. Emotional distress was measured using the Hospital Anxiety and Depression Scale and pain using the subscale of the European Organisation for Research and Treatment of Cancer Quality of Life Core 30 questionnaire. Medical data were obtained from the cancer centre clinical database.

RESULTS: Sleep problems (bothered more than half the days during the previous 2 weeks) were reported by 30.2% (865/2862, 95% CI = 28.5 to 31.9) of the patients. They were common in both patients with active cancer (34.5%) and in cancer survivors (28.0%). There was only a modest association with cancer site and treatment status, but there was a strong association with pain (odds ratio = 2.7, 95% CI = 2.2 to 3.4) and emotional distress (odds ratio = 4.5, 95% CI = 3.7 to 5.6).

CONCLUSIONS: Sleep problems are common in cancer outpatients and are strongly associated with pain and emotional distress. A combined approach to the management of sleep, pain and emotional distress is indicated. Copyright © 2011 John Wiley & Sons, Ltd.

Original languageEnglish
Pages (from-to)1003-9
Number of pages7
JournalPsycho-Oncology
Volume21
Issue number9
Early online date1 Jul 2011
DOIs
Publication statusPublished - Sep 2012

Keywords

  • adolescent
  • adult
  • age distribution
  • aged
  • aged, 80 and over
  • cancer care facilities
  • cross-sectional studies
  • depression
  • female
  • humans
  • male
  • middle aged
  • neoplasms
  • odds ratio
  • outpatients
  • pain
  • prevalence
  • Psychiatric Status Rating Scales
  • quality of life
  • Scotland
  • sleep wake disorders
  • Stress, Psychological
  • surveys and questionnaires
  • young adult
  • Journal Article

Cite this

Sharma, N., Hansen, C. H., O'Connor, M., Thekkumpurath, P., Walker, J., Kleiboer, A., Espie, C., Storey, D., Sharpe, M., & Fleming, L. (2012). Sleep problems in cancer patients: prevalence and association with distress and pain. Psycho-Oncology, 21(9), 1003-9. https://doi.org/10.1002/pon.2004