TY - JOUR
T1 - Sitting time and cardiometabolic risk in US adults
T2 - associations by sex, race, socioeconomic status and activity level
AU - Staiano, A.E.
AU - Harrington, D.M.
AU - Barreira, T.V.
AU - Katzmarzyk, P.T.
N1 - Funding details: National Institute of General Medical Sciences, NIGMS, U54GM104940
Funding details: National Institute of Diabetes and Digestive and Kidney Diseases, NIDDK, T32DK064584
PY - 2014/1/10
Y1 - 2014/1/10
N2 - Background: Sitting time is associated with adverse health outcomes including chronic disease and premature mortality. However, it is not known if the association of sitting time with cardiometabolic risk factors varies across sociodemographic or health factors. Methods: The sample included 4560 adults (≥20 years) who participated in the cross-sectional 2007-2010 US National Health and Nutrition Examination Survey. Participants self-reported typical daily sitting time. Weight, height, blood pressure, and fasting triglycerides, high-density lipoprotein-cholesterol (HDL-C), glucose and insulin were measured. Homeostatic model assessment-insulin resistance (HOMA-IR) and β cell function (HOMA-%B) were calculated. A subsample of 3727 participants underwent an oral glucose tolerance test to obtain 2 h postload glucose levels. Population-weighted linear regression analysis was used to examine the association between sitting time and each cardiometabolic risk factor, stratified by sex, race, socioeconomic status and activity level. Analyses were controlled for demographics, socioeconomic status, survey cycle, personal and family medical history, diet and physical activity. Results: Sitting time was significantly associated with adverse levels of waist circumference, body mass index, triglycerides, HDL-C, insulin, HOMA-IR, HOMA-%B and 2 h postload glucose, but not with blood pressure or glucose level. In stratified analyses, sitting time was most consistently related to cardiometabolic risk factors among low and middle socioeconomic groups and for those who reported no weekly physical activity, but there were few differences between sex or race groups. Conclusions: Self-reported sitting time was associated with adverse cardiometabolic risk factors consistently across sex and race groups in a representative US sample, independent of other risk factors. Excessive sitting warrants a public health concern.
AB - Background: Sitting time is associated with adverse health outcomes including chronic disease and premature mortality. However, it is not known if the association of sitting time with cardiometabolic risk factors varies across sociodemographic or health factors. Methods: The sample included 4560 adults (≥20 years) who participated in the cross-sectional 2007-2010 US National Health and Nutrition Examination Survey. Participants self-reported typical daily sitting time. Weight, height, blood pressure, and fasting triglycerides, high-density lipoprotein-cholesterol (HDL-C), glucose and insulin were measured. Homeostatic model assessment-insulin resistance (HOMA-IR) and β cell function (HOMA-%B) were calculated. A subsample of 3727 participants underwent an oral glucose tolerance test to obtain 2 h postload glucose levels. Population-weighted linear regression analysis was used to examine the association between sitting time and each cardiometabolic risk factor, stratified by sex, race, socioeconomic status and activity level. Analyses were controlled for demographics, socioeconomic status, survey cycle, personal and family medical history, diet and physical activity. Results: Sitting time was significantly associated with adverse levels of waist circumference, body mass index, triglycerides, HDL-C, insulin, HOMA-IR, HOMA-%B and 2 h postload glucose, but not with blood pressure or glucose level. In stratified analyses, sitting time was most consistently related to cardiometabolic risk factors among low and middle socioeconomic groups and for those who reported no weekly physical activity, but there were few differences between sex or race groups. Conclusions: Self-reported sitting time was associated with adverse cardiometabolic risk factors consistently across sex and race groups in a representative US sample, independent of other risk factors. Excessive sitting warrants a public health concern.
KW - adult
KW - aged
KW - ancestry group
KW - article
KW - cardiovascular epidemiology
KW - cross-sectional study
KW - epidemiology
KW - ethnology
KW - exercise
KW - female
KW - human
KW - male
KW - metabolic syndrome X
KW - middle aged
KW - physiology
KW - sedentary lifestyle
KW - self report
KW - sex difference
KW - socioeconomics
KW - statistics
KW - United States
KW - young adult
UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-84894588472&doi=10.1136%2fbjsports-2012-091896&partnerID=40&md5=69dbee29809fd3b1be997c9baaed75b5
U2 - 10.1136/bjsports-2012-091896
DO - 10.1136/bjsports-2012-091896
M3 - Article
SN - 0306-3674
VL - 48
SP - 213
EP - 219
JO - British Journal of Sports Medicine
JF - British Journal of Sports Medicine
IS - 3
ER -