Projects per year
The thalamic reticular nucleus (TRN) is crucial for the modulation of sleep-related oscillations. The caudal and rostral subpopulations of the TRN exert diverse activities, which arise from their interconnectivity with all thalamic nuclei, as well as other brain regions. Despite the recent characterization of the functional and genetic heterogeneity of the TRN, the implications of this heterogeneity for sleep regulation have not been assessed. Here, using a combination of optogenetics and electrophysiology in C57BL/6 mice, we demonstrate that caudal and rostral TRN modulations are associated with changes in cortical alpha and delta oscillations, and have distinct effects on sleep stability. Tonic silencing of the rostral TRN elongates sleep episodes, while tonic silencing of the caudal TRN fragments sleep. Overall, we show evidence of distinct roles exerted by the rostral and caudal TRN in sleep regulation and oscillatory activity.
|Number of pages||16|
|Journal||European Journal of Neuroscience|
|Early online date||9 Jan 2023|
|Publication status||E-pub ahead of print - 9 Jan 2023|
- thalamic reticular nucleus
- sleep spindles
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- 1 Finished
Interrogating the cortico striatal thalamo cortical CSTC circuitry implications for neuropsychiatric drug discovery
Astra Zeneca US, BBSRC (Biotech & Biological Sciences Research Council)
1/10/13 → 30/09/17
Project: Research - Studentship Case