@inbook{7df71827531c40fc9e5ba79204b64442,
title = "siRNA delivery to melanoma cells with cationic niosomes",
abstract = "RNA interference (RNAi) is a posttranscriptional regulatory mechanism that employs siRNA. It typically results in the degradation of a target mRNA that encodes a particular protein. Treatment with siRNA therapeutics requires the use of an effective drug delivery system to assist in delivering these therapeutics into the cytoplasm of the transfected cells. Here we describe the transfection of melanoma cancer cells with siRNA using cationic niosome nanoparticles as a delivery system. The method of niosome preparation is first introduced and is followed by complex formation with siRNA and the transfection method.",
keywords = "niosome nanoparticles, microfluidic mixing, thin-film hydration method, siRNA, cellular transfection, cytotoxicity",
author = "Obeid, {Mohammad A.} and Hanin Alyamani and Haneen Amawi and Aljabali, {Alaa A. A.} and Meriem Rezigue and Abdeljaber, {Shatha N.} and Ferro, {Valerie A.}",
year = "2021",
month = mar,
day = "12",
doi = "10.1007/978-1-0716-1205-7_42",
language = "English",
isbn = "9781071612040",
series = "Methods in Molecular Biology",
publisher = "Springer Verlag",
pages = "621--634",
editor = "K.M. Hargadon",
booktitle = "Melanoma",
}