Single bubble acoustic characterization and stability measurement of adherent microbubbles

Jonathan Casey; Charles Sennoga; Helen Mulvana; Jo V. Hajnal; Meng-Xing Tang; Robert J. Eckersley

doi:10.1016/j.ultrasmedbio.2012.12.007

Single bubble acoustic characterization and stability measurement of adherent microbubbles

Jonathan Casey, Charles Sennoga, Helen Mulvana, Jo V. Hajnal, Meng-Xing Tang, Robert J. Eckersley

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

This article examines how the acoustic and stability characteristics of single lipid-shelled microbubbles (MBs) change as a result of adherence to a target surface. For individual adherent and non-adherent MBs, the backscattered echo from a narrowband 2-MHz, 90-kPa peak negative pressure interrogation pulse was obtained. These measurements were made in conjunction with an increasing amplitude broadband disruption pulse. It was found that, for the given driving frequency, adherence had little effect on the fundamental response of an MB. Examination of the second harmonic response indicated an increase of the resonance frequency for an adherent MB: resonance radius increasing of 0.3 ± 0.1 μm for an adherent MB. MB stability was seen to be closely related to MB resonance and gave further evidence of a change in the resonance frequency due to adherence.

Original language	English
Pages (from-to)	903-914
Number of pages	12
Journal	Ultrasound in Medicine and Biology
Volume	39
Issue number	5
Early online date	6 Mar 2013
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2012.12.007
Publication status	Published - 31 May 2013

Keywords

ultrasound
microbubbles
targeting
adherence
resonance
stability

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10.1016/j.ultrasmedbio.2012.12.007

Cite this

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title = "Single bubble acoustic characterization and stability measurement of adherent microbubbles",

abstract = "This article examines how the acoustic and stability characteristics of single lipid-shelled microbubbles (MBs) change as a result of adherence to a target surface. For individual adherent and non-adherent MBs, the backscattered echo from a narrowband 2-MHz, 90-kPa peak negative pressure interrogation pulse was obtained. These measurements were made in conjunction with an increasing amplitude broadband disruption pulse. It was found that, for the given driving frequency, adherence had little effect on the fundamental response of an MB. Examination of the second harmonic response indicated an increase of the resonance frequency for an adherent MB: resonance radius increasing of 0.3 ± 0.1 μm for an adherent MB. MB stability was seen to be closely related to MB resonance and gave further evidence of a change in the resonance frequency due to adherence.",

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AU - Casey, Jonathan

AU - Sennoga, Charles

AU - Mulvana, Helen

AU - Hajnal, Jo V.

AU - Tang, Meng-Xing

AU - Eckersley, Robert J.

PY - 2013/5/31

Y1 - 2013/5/31

N2 - This article examines how the acoustic and stability characteristics of single lipid-shelled microbubbles (MBs) change as a result of adherence to a target surface. For individual adherent and non-adherent MBs, the backscattered echo from a narrowband 2-MHz, 90-kPa peak negative pressure interrogation pulse was obtained. These measurements were made in conjunction with an increasing amplitude broadband disruption pulse. It was found that, for the given driving frequency, adherence had little effect on the fundamental response of an MB. Examination of the second harmonic response indicated an increase of the resonance frequency for an adherent MB: resonance radius increasing of 0.3 ± 0.1 μm for an adherent MB. MB stability was seen to be closely related to MB resonance and gave further evidence of a change in the resonance frequency due to adherence.

AB - This article examines how the acoustic and stability characteristics of single lipid-shelled microbubbles (MBs) change as a result of adherence to a target surface. For individual adherent and non-adherent MBs, the backscattered echo from a narrowband 2-MHz, 90-kPa peak negative pressure interrogation pulse was obtained. These measurements were made in conjunction with an increasing amplitude broadband disruption pulse. It was found that, for the given driving frequency, adherence had little effect on the fundamental response of an MB. Examination of the second harmonic response indicated an increase of the resonance frequency for an adherent MB: resonance radius increasing of 0.3 ± 0.1 μm for an adherent MB. MB stability was seen to be closely related to MB resonance and gave further evidence of a change in the resonance frequency due to adherence.

KW - ultrasound

KW - microbubbles

KW - targeting

KW - adherence

KW - resonance

KW - stability

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DO - 10.1016/j.ultrasmedbio.2012.12.007

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EP - 914

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

IS - 5

ER -

Single bubble acoustic characterization and stability measurement of adherent microbubbles

Abstract

Keywords

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