Simulation of flow diversion in cerebral aneurysms

A. Kazakidi, F. Drakopoulos, C. Sadasivan, N. Chrisochoides, J. Ekaterinaris, B. B. Lieber

Research output: Contribution to conferenceAbstract

Abstract

Intracranial aneurysms are abnormal focal enlargements of the vascular walls that necessitate surgical intervention once detected. Emerging stent technology involves an innovative type of finely-braided stents, called flow diverters, which abruptly impede the arterial flow into the aneurysm, upon deployment, and induce thrombosis, vascular remodelling and complete aneurysm occlusion in under a year [1]. The understanding of the dynamics of blood flow within this radically modified environment is thought to be pivotal in increasing the efficacy of both stent design and prolonged treatment. The aim of this study is to numerically simulate the blood flow within stented arterial segments and to evaluate critical hemodynamic factors around the aneurysm neck, validated with clinical and experimental data [1,2]. These objectives create many geometric challenges around the flow diverter due to the tessellation and resolution of features with very large ratio (artery-to-stent) in the input i.e., medical images and stent models. Following a novel Body-Centric Cubic (BCC) mesh generation method [2], high-fidelity tetrahedral meshes of aneurysmal dilatations that incorporate flow diverters across the aneurysm neck are now possible with an accurate image- to-mesh (I2M) conversion scheme from micro-CT images (Fig. 1a,b). Preliminary results involve arterial segments both with and without flow diverters (Fig.1c), utilising the CFD software OpenFOAM® to solve the incompressible Navier-Stokes equations, under steady and physiologically-correct pulsatile flow conditions.

Conference

Conference7th European Congress on Computational Methods in Applied Sciences and Engineering, ECCOMAS Congress 2016
CountryGreece
CityCrete
Period5/06/1610/06/16

Fingerprint

Stents
Blood
Pulsatile flow
Mesh generation
Hemodynamics
Navier Stokes equations
Computational fluid dynamics

Keywords

  • intracranial aneurysms
  • surgical intervention
  • blood flow

Cite this

Kazakidi, A., Drakopoulos, F., Sadasivan, C., Chrisochoides, N., Ekaterinaris, J., & Lieber, B. B. (2016). Simulation of flow diversion in cerebral aneurysms. Abstract from 7th European Congress on Computational Methods in Applied Sciences and Engineering, ECCOMAS Congress 2016, Crete, Greece.
Kazakidi, A. ; Drakopoulos, F. ; Sadasivan, C. ; Chrisochoides, N. ; Ekaterinaris, J. ; Lieber, B. B. / Simulation of flow diversion in cerebral aneurysms. Abstract from 7th European Congress on Computational Methods in Applied Sciences and Engineering, ECCOMAS Congress 2016, Crete, Greece.1 p.
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Kazakidi, A, Drakopoulos, F, Sadasivan, C, Chrisochoides, N, Ekaterinaris, J & Lieber, BB 2016, 'Simulation of flow diversion in cerebral aneurysms' 7th European Congress on Computational Methods in Applied Sciences and Engineering, ECCOMAS Congress 2016, Crete, Greece, 5/06/16 - 10/06/16, .

Simulation of flow diversion in cerebral aneurysms. / Kazakidi, A.; Drakopoulos, F.; Sadasivan, C.; Chrisochoides, N.; Ekaterinaris, J.; Lieber, B. B.

2016. Abstract from 7th European Congress on Computational Methods in Applied Sciences and Engineering, ECCOMAS Congress 2016, Crete, Greece.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Simulation of flow diversion in cerebral aneurysms

AU - Kazakidi, A.

AU - Drakopoulos, F.

AU - Sadasivan, C.

AU - Chrisochoides, N.

AU - Ekaterinaris, J.

AU - Lieber, B. B.

PY - 2016/6/5

Y1 - 2016/6/5

N2 - Intracranial aneurysms are abnormal focal enlargements of the vascular walls that necessitate surgical intervention once detected. Emerging stent technology involves an innovative type of finely-braided stents, called flow diverters, which abruptly impede the arterial flow into the aneurysm, upon deployment, and induce thrombosis, vascular remodelling and complete aneurysm occlusion in under a year [1]. The understanding of the dynamics of blood flow within this radically modified environment is thought to be pivotal in increasing the efficacy of both stent design and prolonged treatment. The aim of this study is to numerically simulate the blood flow within stented arterial segments and to evaluate critical hemodynamic factors around the aneurysm neck, validated with clinical and experimental data [1,2]. These objectives create many geometric challenges around the flow diverter due to the tessellation and resolution of features with very large ratio (artery-to-stent) in the input i.e., medical images and stent models. Following a novel Body-Centric Cubic (BCC) mesh generation method [2], high-fidelity tetrahedral meshes of aneurysmal dilatations that incorporate flow diverters across the aneurysm neck are now possible with an accurate image- to-mesh (I2M) conversion scheme from micro-CT images (Fig. 1a,b). Preliminary results involve arterial segments both with and without flow diverters (Fig.1c), utilising the CFD software OpenFOAM® to solve the incompressible Navier-Stokes equations, under steady and physiologically-correct pulsatile flow conditions.

AB - Intracranial aneurysms are abnormal focal enlargements of the vascular walls that necessitate surgical intervention once detected. Emerging stent technology involves an innovative type of finely-braided stents, called flow diverters, which abruptly impede the arterial flow into the aneurysm, upon deployment, and induce thrombosis, vascular remodelling and complete aneurysm occlusion in under a year [1]. The understanding of the dynamics of blood flow within this radically modified environment is thought to be pivotal in increasing the efficacy of both stent design and prolonged treatment. The aim of this study is to numerically simulate the blood flow within stented arterial segments and to evaluate critical hemodynamic factors around the aneurysm neck, validated with clinical and experimental data [1,2]. These objectives create many geometric challenges around the flow diverter due to the tessellation and resolution of features with very large ratio (artery-to-stent) in the input i.e., medical images and stent models. Following a novel Body-Centric Cubic (BCC) mesh generation method [2], high-fidelity tetrahedral meshes of aneurysmal dilatations that incorporate flow diverters across the aneurysm neck are now possible with an accurate image- to-mesh (I2M) conversion scheme from micro-CT images (Fig. 1a,b). Preliminary results involve arterial segments both with and without flow diverters (Fig.1c), utilising the CFD software OpenFOAM® to solve the incompressible Navier-Stokes equations, under steady and physiologically-correct pulsatile flow conditions.

KW - intracranial aneurysms

KW - surgical intervention

KW - blood flow

UR - https://www.eccomas2016.org/

M3 - Abstract

ER -

Kazakidi A, Drakopoulos F, Sadasivan C, Chrisochoides N, Ekaterinaris J, Lieber BB. Simulation of flow diversion in cerebral aneurysms. 2016. Abstract from 7th European Congress on Computational Methods in Applied Sciences and Engineering, ECCOMAS Congress 2016, Crete, Greece.