Abstract
Many drug molecules have low solubility in aqueous media and, hence, poor bioavailability. The formation of a host-guest complex with some other compound which has a good solubility profile can facilitate solubilization of hydrophobic drugs. Complex formation relies upon the formation of non-covalent interactions between the host molecule and the drug guest. The use of calix[n]arenes, a well-characterized class of cyclic oligomers, has been investigated for their ability to form complexes with a variety of ionic and molecular species. This review highlights those studies which have demonstrated the potential of calix[n]arenes as host molecules in novel drug delivery systems.
| Original language | English |
|---|---|
| Article number | 00028 |
| Number of pages | 8 |
| Journal | Journal of Nanomedicine Research |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 20 Apr 2015 |
Keywords
- calix[n]arene
- drug solubilization
- calix[4]resorcinarene
- bioavailability