Simple calix[n]arenes and calix[4]resorcinarenes as drug solubilizing agents

Clare Hoskins; Anthony D.M. Curtis

doi:10.15406/jnmr.2015.02.00028

Simple calix[n]arenes and calix[4]resorcinarenes as drug solubilizing agents

Clare Hoskins, Anthony D.M. Curtis

Pure And Applied Chemistry

Research output: Contribution to journal › Review article

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Abstract

Many drug molecules have low solubility in aqueous media and, hence, poor bioavailability. The formation of a host-guest complex with some other compound which has a good solubility profile can facilitate solubilization of hydrophobic drugs. Complex formation relies upon the formation of non-covalent interactions between the host molecule and the drug guest. The use of calix[n]arenes, a well-characterized class of cyclic oligomers, has been investigated for their ability to form complexes with a variety of ionic and molecular species. This review highlights those studies which have demonstrated the potential of calix[n]arenes as host molecules in novel drug delivery systems.

Original language	English
Article number	00028
Number of pages	8
Journal	Journal of Nanomedicine Research
Volume	2
Issue number	3
DOIs	https://doi.org/10.15406/jnmr.2015.02.00028
Publication status	Published - 20 Apr 2015

Keywords

calix[n]arene
drug solubilization
calix[4]resorcinarene
bioavailability

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10.15406/jnmr.2015.02.00028Licence: CC BY 4.0

Hoskins-Curtis-JNR2015-Simple-calix[n]arenes-calix[4]resorcinarenes-drug-solubilizing-agentsFinal published version, 993 KBLicence: CC BY 4.0

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N2 - Many drug molecules have low solubility in aqueous media and, hence, poor bioavailability. The formation of a host-guest complex with some other compound which has a good solubility profile can facilitate solubilization of hydrophobic drugs. Complex formation relies upon the formation of non-covalent interactions between the host molecule and the drug guest. The use of calix[n]arenes, a well-characterized class of cyclic oligomers, has been investigated for their ability to form complexes with a variety of ionic and molecular species. This review highlights those studies which have demonstrated the potential of calix[n]arenes as host molecules in novel drug delivery systems.

AB - Many drug molecules have low solubility in aqueous media and, hence, poor bioavailability. The formation of a host-guest complex with some other compound which has a good solubility profile can facilitate solubilization of hydrophobic drugs. Complex formation relies upon the formation of non-covalent interactions between the host molecule and the drug guest. The use of calix[n]arenes, a well-characterized class of cyclic oligomers, has been investigated for their ability to form complexes with a variety of ionic and molecular species. This review highlights those studies which have demonstrated the potential of calix[n]arenes as host molecules in novel drug delivery systems.

KW - calix[n]arene

KW - drug solubilization

KW - calix[4]resorcinarene

KW - bioavailability

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