Simple calix[n]arenes and calix[4]resorcinarenes as drug solubilizing agents

Clare Hoskins, Anthony D.M. Curtis

Research output: Contribution to journalReview article

Abstract

Many drug molecules have low solubility in aqueous media and, hence, poor bioavailability. The formation of a host-guest complex with some other compound which has a good solubility profile can facilitate solubilization of hydrophobic drugs. Complex formation relies upon the formation of non-covalent interactions between the host molecule and the drug guest. The use of calix[n]arenes, a well-characterized class of cyclic oligomers, has been investigated for their ability to form complexes with a variety of ionic and molecular species. This review highlights those studies which have demonstrated the potential of calix[n]arenes as host molecules in novel drug delivery systems.
Original languageEnglish
Article number00028
Number of pages8
JournalJournal of Nanomedicine Research
Volume2
Issue number3
DOIs
Publication statusPublished - 20 Apr 2015

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Calixarenes
Solubility
Molecules
Pharmaceutical Preparations
Drug Delivery Systems
Oligomers
Biological Availability

Keywords

  • calix[n]arene
  • drug solubilization
  • calix[4]resorcinarene
  • bioavailability

Cite this

Hoskins, Clare ; Curtis, Anthony D.M. / Simple calix[n]arenes and calix[4]resorcinarenes as drug solubilizing agents. In: Journal of Nanomedicine Research. 2015 ; Vol. 2, No. 3.
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Simple calix[n]arenes and calix[4]resorcinarenes as drug solubilizing agents. / Hoskins, Clare; Curtis, Anthony D.M.

In: Journal of Nanomedicine Research, Vol. 2, No. 3, 00028, 20.04.2015.

Research output: Contribution to journalReview article

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AU - Curtis, Anthony D.M.

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N2 - Many drug molecules have low solubility in aqueous media and, hence, poor bioavailability. The formation of a host-guest complex with some other compound which has a good solubility profile can facilitate solubilization of hydrophobic drugs. Complex formation relies upon the formation of non-covalent interactions between the host molecule and the drug guest. The use of calix[n]arenes, a well-characterized class of cyclic oligomers, has been investigated for their ability to form complexes with a variety of ionic and molecular species. This review highlights those studies which have demonstrated the potential of calix[n]arenes as host molecules in novel drug delivery systems.

AB - Many drug molecules have low solubility in aqueous media and, hence, poor bioavailability. The formation of a host-guest complex with some other compound which has a good solubility profile can facilitate solubilization of hydrophobic drugs. Complex formation relies upon the formation of non-covalent interactions between the host molecule and the drug guest. The use of calix[n]arenes, a well-characterized class of cyclic oligomers, has been investigated for their ability to form complexes with a variety of ionic and molecular species. This review highlights those studies which have demonstrated the potential of calix[n]arenes as host molecules in novel drug delivery systems.

KW - calix[n]arene

KW - drug solubilization

KW - calix[4]resorcinarene

KW - bioavailability

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DO - 10.15406/jnmr.2015.02.00028

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