Sialoadhesin promotes the inflammatory response in experimental autoimmune uveoretinitis

Hui-Rong Jiang, Lenias Hwenda, Kimmo Makinen, Cornelia Oetke, Paul R. Crocker, John V. Forrester

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Macrophages are a prominent component of the effector cell compartment in a number of CD4+ T cell-mediated organ-specific autoimmune diseases. In this study, we investigated the role of the sialic acid binding Ig-like lectin sialoadhesin (Sn, Siglec-1) in a model of interphotoreceptor retinal binding protein peptide-induced experimental autoimmune uveoretinitis in mice with targeted deletion of Sn. Our data show that compared with wild-type mice, experimental autoimmune uveoretinitis is reduced in severity in the initial stages in the Sn knockout (KO) mice. In addition, there is a reduction in the proliferative capacity of T cells from the KO mice draining lymph nodes after immunization with interphotoreceptor retinal binding protein peptides, which is manifest some days before disease onset and persists for the duration of disease. Furthermore, activated T cells from the draining lymph nodes of Sn KO mice secrete lower levels of IFN-gamma. The data suggest a role for Sn in "fine tuning" the immune response to autoantigens by modulating T cell priming.

Original languageEnglish
Pages (from-to)2258-2264
Number of pages7
JournalJournal of Immunology
Volume177
Issue number4
DOIs
Publication statusPublished - 15 Aug 2006

Fingerprint

Sialic Acid Binding Ig-like Lectin 1
Knockout Mice
T-Lymphocytes
Carrier Proteins
Sialic Acid Binding Immunoglobulin-like Lectins
Lymph Nodes
Peptides
Cellular Structures
Autoimmune Diseases
Immunization
Macrophages

Keywords

  • amino acid sequence
  • animals
  • autoantigens
  • autoimmune diseases
  • disease models, animal
  • inflammation
  • lymphocyte activation
  • membrane glycoproteins
  • mice
  • mice, inbred C57BL
  • mice, knockout
  • molecular sequence data
  • receptors, immunologic
  • retinitis
  • severity of illness index
  • sialic acid binding Ig-like lectin 1
  • T-Lymphocytes
  • uveitis

Cite this

Jiang, Hui-Rong ; Hwenda, Lenias ; Makinen, Kimmo ; Oetke, Cornelia ; Crocker, Paul R. ; Forrester, John V. / Sialoadhesin promotes the inflammatory response in experimental autoimmune uveoretinitis. In: Journal of Immunology . 2006 ; Vol. 177, No. 4. pp. 2258-2264.
@article{c9cd8913b5504a578a50182b5036fd0b,
title = "Sialoadhesin promotes the inflammatory response in experimental autoimmune uveoretinitis",
abstract = "Macrophages are a prominent component of the effector cell compartment in a number of CD4+ T cell-mediated organ-specific autoimmune diseases. In this study, we investigated the role of the sialic acid binding Ig-like lectin sialoadhesin (Sn, Siglec-1) in a model of interphotoreceptor retinal binding protein peptide-induced experimental autoimmune uveoretinitis in mice with targeted deletion of Sn. Our data show that compared with wild-type mice, experimental autoimmune uveoretinitis is reduced in severity in the initial stages in the Sn knockout (KO) mice. In addition, there is a reduction in the proliferative capacity of T cells from the KO mice draining lymph nodes after immunization with interphotoreceptor retinal binding protein peptides, which is manifest some days before disease onset and persists for the duration of disease. Furthermore, activated T cells from the draining lymph nodes of Sn KO mice secrete lower levels of IFN-gamma. The data suggest a role for Sn in {"}fine tuning{"} the immune response to autoantigens by modulating T cell priming.",
keywords = "amino acid sequence, animals, autoantigens, autoimmune diseases, disease models, animal, inflammation, lymphocyte activation, membrane glycoproteins, mice, mice, inbred C57BL, mice, knockout, molecular sequence data, receptors, immunologic, retinitis, severity of illness index, sialic acid binding Ig-like lectin 1, T-Lymphocytes, uveitis",
author = "Hui-Rong Jiang and Lenias Hwenda and Kimmo Makinen and Cornelia Oetke and Crocker, {Paul R.} and Forrester, {John V.}",
year = "2006",
month = "8",
day = "15",
doi = "10.4049/jimmunol.177.4.2258",
language = "English",
volume = "177",
pages = "2258--2264",
journal = "Journal of Immunology",
issn = "0022-1767",
number = "4",

}

Sialoadhesin promotes the inflammatory response in experimental autoimmune uveoretinitis. / Jiang, Hui-Rong; Hwenda, Lenias; Makinen, Kimmo; Oetke, Cornelia; Crocker, Paul R.; Forrester, John V.

In: Journal of Immunology , Vol. 177, No. 4, 15.08.2006, p. 2258-2264.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sialoadhesin promotes the inflammatory response in experimental autoimmune uveoretinitis

AU - Jiang, Hui-Rong

AU - Hwenda, Lenias

AU - Makinen, Kimmo

AU - Oetke, Cornelia

AU - Crocker, Paul R.

AU - Forrester, John V.

PY - 2006/8/15

Y1 - 2006/8/15

N2 - Macrophages are a prominent component of the effector cell compartment in a number of CD4+ T cell-mediated organ-specific autoimmune diseases. In this study, we investigated the role of the sialic acid binding Ig-like lectin sialoadhesin (Sn, Siglec-1) in a model of interphotoreceptor retinal binding protein peptide-induced experimental autoimmune uveoretinitis in mice with targeted deletion of Sn. Our data show that compared with wild-type mice, experimental autoimmune uveoretinitis is reduced in severity in the initial stages in the Sn knockout (KO) mice. In addition, there is a reduction in the proliferative capacity of T cells from the KO mice draining lymph nodes after immunization with interphotoreceptor retinal binding protein peptides, which is manifest some days before disease onset and persists for the duration of disease. Furthermore, activated T cells from the draining lymph nodes of Sn KO mice secrete lower levels of IFN-gamma. The data suggest a role for Sn in "fine tuning" the immune response to autoantigens by modulating T cell priming.

AB - Macrophages are a prominent component of the effector cell compartment in a number of CD4+ T cell-mediated organ-specific autoimmune diseases. In this study, we investigated the role of the sialic acid binding Ig-like lectin sialoadhesin (Sn, Siglec-1) in a model of interphotoreceptor retinal binding protein peptide-induced experimental autoimmune uveoretinitis in mice with targeted deletion of Sn. Our data show that compared with wild-type mice, experimental autoimmune uveoretinitis is reduced in severity in the initial stages in the Sn knockout (KO) mice. In addition, there is a reduction in the proliferative capacity of T cells from the KO mice draining lymph nodes after immunization with interphotoreceptor retinal binding protein peptides, which is manifest some days before disease onset and persists for the duration of disease. Furthermore, activated T cells from the draining lymph nodes of Sn KO mice secrete lower levels of IFN-gamma. The data suggest a role for Sn in "fine tuning" the immune response to autoantigens by modulating T cell priming.

KW - amino acid sequence

KW - animals

KW - autoantigens

KW - autoimmune diseases

KW - disease models, animal

KW - inflammation

KW - lymphocyte activation

KW - membrane glycoproteins

KW - mice

KW - mice, inbred C57BL

KW - mice, knockout

KW - molecular sequence data

KW - receptors, immunologic

KW - retinitis

KW - severity of illness index

KW - sialic acid binding Ig-like lectin 1

KW - T-Lymphocytes

KW - uveitis

UR - http://www.jimmunol.org/

U2 - 10.4049/jimmunol.177.4.2258

DO - 10.4049/jimmunol.177.4.2258

M3 - Article

VL - 177

SP - 2258

EP - 2264

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 4

ER -