Short-term memory binding is impaired in AD but not in non-AD dementias

Sergio Della Sala, Mario A. Parra, Katia Fabia, Simona Luzzi, Sharon Abrahams

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Binding is a cognitive function responsible for integrating features within complex stimuli (e.g., shapecolour conjunctions) or events within complex memories (e.g., face-name associations). This function operates both in short-term memory (STM) and in long-term memory (LTM) and is severely affected by Alzheimer’s disease (AD). However, forming conjunctions in STM is the only binding function which is not affected by healthy ageing or chronic depression. Whether this specificity holds true across other non-AD dementias is as yet unknown. The present study investigated STM conjunctive binding in a sample of AD patients and patients with other non-AD dementias using a task which has proved sensitive to the effects of AD. The STM task assesses the free recall of objects, colours, and the bindings of objects and colours. Patients with AD, frontotemporal dementia, vascular dementia, lewy body dementia anddementia associated with Parkinson’s disease showed memory, visuo-spatial, executive and attentional deficits on standard neuropsychological assessment. However, only AD patients showed STM binding deficits. This deficit was observed even when memory for single features was at a similar level acrosspatient groups. Regression and discriminant analyses confirmed that the STM binding task accounted for the largest proportion of variance between AD and non-AD groups and held the greatest classification power to identify patients with AD. STM conjunctive binding places little demands on executive functionsand appears to be subserved by components of the memory network which are targeted by AD, but not by non-AD dementias.
LanguageEnglish
Pages833-840
Number of pages8
JournalNeuropsychologia
Volume50
Issue number5
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Short-Term Memory
Dementia
Alzheimer Disease
Color
Lewy Body Disease
Frontotemporal Dementia
Vascular Dementia
Long-Term Memory
Memory Disorders
Discriminant Analysis
Cognition
Names
Parkinson Disease
Regression Analysis
Depression

Keywords

  • sporadic Alzheimer's disease
  • non-Alzheimer's dementias
  • differential diagnosis
  • short-term memory binding
  • working memory

Cite this

Della Sala, Sergio ; Parra, Mario A. ; Fabia, Katia ; Luzzi, Simona ; Abrahams, Sharon. / Short-term memory binding is impaired in AD but not in non-AD dementias. In: Neuropsychologia. 2012 ; Vol. 50, No. 5. pp. 833-840.
@article{03998866802a4a6c9ecac2dba6f50d14,
title = "Short-term memory binding is impaired in AD but not in non-AD dementias",
abstract = "Binding is a cognitive function responsible for integrating features within complex stimuli (e.g., shapecolour conjunctions) or events within complex memories (e.g., face-name associations). This function operates both in short-term memory (STM) and in long-term memory (LTM) and is severely affected by Alzheimer’s disease (AD). However, forming conjunctions in STM is the only binding function which is not affected by healthy ageing or chronic depression. Whether this specificity holds true across other non-AD dementias is as yet unknown. The present study investigated STM conjunctive binding in a sample of AD patients and patients with other non-AD dementias using a task which has proved sensitive to the effects of AD. The STM task assesses the free recall of objects, colours, and the bindings of objects and colours. Patients with AD, frontotemporal dementia, vascular dementia, lewy body dementia anddementia associated with Parkinson’s disease showed memory, visuo-spatial, executive and attentional deficits on standard neuropsychological assessment. However, only AD patients showed STM binding deficits. This deficit was observed even when memory for single features was at a similar level acrosspatient groups. Regression and discriminant analyses confirmed that the STM binding task accounted for the largest proportion of variance between AD and non-AD groups and held the greatest classification power to identify patients with AD. STM conjunctive binding places little demands on executive functionsand appears to be subserved by components of the memory network which are targeted by AD, but not by non-AD dementias.",
keywords = "sporadic Alzheimer's disease, non-Alzheimer's dementias, differential diagnosis, short-term memory binding, working memory",
author = "{Della Sala}, Sergio and Parra, {Mario A.} and Katia Fabia and Simona Luzzi and Sharon Abrahams",
year = "2012",
month = "4",
doi = "10.1016/j.neuropsychologia.2012.01.018",
language = "English",
volume = "50",
pages = "833--840",
journal = "Neuropsychologia",
issn = "0028-3932",
number = "5",

}

Short-term memory binding is impaired in AD but not in non-AD dementias. / Della Sala, Sergio; Parra, Mario A.; Fabia, Katia; Luzzi, Simona ; Abrahams, Sharon.

In: Neuropsychologia, Vol. 50, No. 5, 04.2012, p. 833-840.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Short-term memory binding is impaired in AD but not in non-AD dementias

AU - Della Sala, Sergio

AU - Parra, Mario A.

AU - Fabia, Katia

AU - Luzzi, Simona

AU - Abrahams, Sharon

PY - 2012/4

Y1 - 2012/4

N2 - Binding is a cognitive function responsible for integrating features within complex stimuli (e.g., shapecolour conjunctions) or events within complex memories (e.g., face-name associations). This function operates both in short-term memory (STM) and in long-term memory (LTM) and is severely affected by Alzheimer’s disease (AD). However, forming conjunctions in STM is the only binding function which is not affected by healthy ageing or chronic depression. Whether this specificity holds true across other non-AD dementias is as yet unknown. The present study investigated STM conjunctive binding in a sample of AD patients and patients with other non-AD dementias using a task which has proved sensitive to the effects of AD. The STM task assesses the free recall of objects, colours, and the bindings of objects and colours. Patients with AD, frontotemporal dementia, vascular dementia, lewy body dementia anddementia associated with Parkinson’s disease showed memory, visuo-spatial, executive and attentional deficits on standard neuropsychological assessment. However, only AD patients showed STM binding deficits. This deficit was observed even when memory for single features was at a similar level acrosspatient groups. Regression and discriminant analyses confirmed that the STM binding task accounted for the largest proportion of variance between AD and non-AD groups and held the greatest classification power to identify patients with AD. STM conjunctive binding places little demands on executive functionsand appears to be subserved by components of the memory network which are targeted by AD, but not by non-AD dementias.

AB - Binding is a cognitive function responsible for integrating features within complex stimuli (e.g., shapecolour conjunctions) or events within complex memories (e.g., face-name associations). This function operates both in short-term memory (STM) and in long-term memory (LTM) and is severely affected by Alzheimer’s disease (AD). However, forming conjunctions in STM is the only binding function which is not affected by healthy ageing or chronic depression. Whether this specificity holds true across other non-AD dementias is as yet unknown. The present study investigated STM conjunctive binding in a sample of AD patients and patients with other non-AD dementias using a task which has proved sensitive to the effects of AD. The STM task assesses the free recall of objects, colours, and the bindings of objects and colours. Patients with AD, frontotemporal dementia, vascular dementia, lewy body dementia anddementia associated with Parkinson’s disease showed memory, visuo-spatial, executive and attentional deficits on standard neuropsychological assessment. However, only AD patients showed STM binding deficits. This deficit was observed even when memory for single features was at a similar level acrosspatient groups. Regression and discriminant analyses confirmed that the STM binding task accounted for the largest proportion of variance between AD and non-AD groups and held the greatest classification power to identify patients with AD. STM conjunctive binding places little demands on executive functionsand appears to be subserved by components of the memory network which are targeted by AD, but not by non-AD dementias.

KW - sporadic Alzheimer's disease

KW - non-Alzheimer's dementias

KW - differential diagnosis

KW - short-term memory binding

KW - working memory

UR - http://www.scopus.com/inward/record.url?scp=84858441526&partnerID=8YFLogxK

U2 - 10.1016/j.neuropsychologia.2012.01.018

DO - 10.1016/j.neuropsychologia.2012.01.018

M3 - Article

VL - 50

SP - 833

EP - 840

JO - Neuropsychologia

T2 - Neuropsychologia

JF - Neuropsychologia

SN - 0028-3932

IS - 5

ER -