Short-term memory binding in mild cognitive impairment

Sara Fernández-Guinea, Mario A Parra, Anna Frank, M Luisa Delgado, Sergio Della Sala

Research output: Contribution to conferencePaper

Abstract

We showed that short-term memory (STM) binding is sensitive to sporadic and familial Alzheimer's disease (AD) but is not affected by healthy ageing, chronic depression in the elderly or other forms of dementia. STM binding deficits were also observed in individuals with a genetic susceptibility for AD in the preclinical stages. Hence, we aim to investigate longitudinally individuals with Mild Cognitive Impairment (MCI) using STM binding tasks. Here we report on preliminary cross-sectional results. A comprehensive neuropsychological test battery and a visual STM task were given to 21 MCI patients and 20 controls. The STM task required participants to recognise changes across two consecutive arrays presenting either single features (colour or shape) or feature bindings. The MCI group performed significantly poorer than controls on standard tests of memory, attention and on the binding condition of the STM task, but not on single feature conditions. Performance on the binding task and on standard memory tests did not correlate. Eight MCI patients clearly performed outwith the range of normality in the binding task. However, they did not significantly differ from the other 13 MCI patients in disease severity or demographic and neuropsychological variables. Six patients with binding impairments showed a multiple domain profile whereas ten patients with a preserved binding function showed an amnesic profile [Chi-square = 5.45, p = 0.020]. These results suggest that (1) the binding task is assessing a function different from other memory tests and that (2) STM binding may be differentially impaired in MCI subgroups.

Conference

Conference3rd International Scientific Meeting of the Federation of the European Societies for Neuropsychology
CountrySwitzerland
CityBasel
Period7/09/119/09/11

Fingerprint

Short-Term Memory
Alzheimer Disease
Neuropsychological Tests
Memory Disorders
Genetic Predisposition to Disease
Cognitive Dysfunction
Dementia
Color
Demography
Depression

Keywords

  • short-term memory
  • Alzheimer's
  • dementia

Cite this

Fernández-Guinea, S., Parra, M. A., Frank, A., Delgado, M. L., & Della Sala, S. (2011). Short-term memory binding in mild cognitive impairment. Paper presented at 3rd International Scientific Meeting of the Federation of the European Societies for Neuropsychology, Basel, Switzerland.
Fernández-Guinea, Sara ; Parra, Mario A ; Frank, Anna ; Delgado, M Luisa ; Della Sala, Sergio. / Short-term memory binding in mild cognitive impairment. Paper presented at 3rd International Scientific Meeting of the Federation of the European Societies for Neuropsychology, Basel, Switzerland.1 p.
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Fernández-Guinea, S, Parra, MA, Frank, A, Delgado, ML & Della Sala, S 2011, 'Short-term memory binding in mild cognitive impairment' Paper presented at 3rd International Scientific Meeting of the Federation of the European Societies for Neuropsychology, Basel, Switzerland, 7/09/11 - 9/09/11, .

Short-term memory binding in mild cognitive impairment. / Fernández-Guinea, Sara; Parra, Mario A; Frank, Anna; Delgado, M Luisa; Della Sala, Sergio.

2011. Paper presented at 3rd International Scientific Meeting of the Federation of the European Societies for Neuropsychology, Basel, Switzerland.

Research output: Contribution to conferencePaper

TY - CONF

T1 - Short-term memory binding in mild cognitive impairment

AU - Fernández-Guinea, Sara

AU - Parra, Mario A

AU - Frank, Anna

AU - Delgado, M Luisa

AU - Della Sala, Sergio

PY - 2011/9/7

Y1 - 2011/9/7

N2 - We showed that short-term memory (STM) binding is sensitive to sporadic and familial Alzheimer's disease (AD) but is not affected by healthy ageing, chronic depression in the elderly or other forms of dementia. STM binding deficits were also observed in individuals with a genetic susceptibility for AD in the preclinical stages. Hence, we aim to investigate longitudinally individuals with Mild Cognitive Impairment (MCI) using STM binding tasks. Here we report on preliminary cross-sectional results. A comprehensive neuropsychological test battery and a visual STM task were given to 21 MCI patients and 20 controls. The STM task required participants to recognise changes across two consecutive arrays presenting either single features (colour or shape) or feature bindings. The MCI group performed significantly poorer than controls on standard tests of memory, attention and on the binding condition of the STM task, but not on single feature conditions. Performance on the binding task and on standard memory tests did not correlate. Eight MCI patients clearly performed outwith the range of normality in the binding task. However, they did not significantly differ from the other 13 MCI patients in disease severity or demographic and neuropsychological variables. Six patients with binding impairments showed a multiple domain profile whereas ten patients with a preserved binding function showed an amnesic profile [Chi-square = 5.45, p = 0.020]. These results suggest that (1) the binding task is assessing a function different from other memory tests and that (2) STM binding may be differentially impaired in MCI subgroups.

AB - We showed that short-term memory (STM) binding is sensitive to sporadic and familial Alzheimer's disease (AD) but is not affected by healthy ageing, chronic depression in the elderly or other forms of dementia. STM binding deficits were also observed in individuals with a genetic susceptibility for AD in the preclinical stages. Hence, we aim to investigate longitudinally individuals with Mild Cognitive Impairment (MCI) using STM binding tasks. Here we report on preliminary cross-sectional results. A comprehensive neuropsychological test battery and a visual STM task were given to 21 MCI patients and 20 controls. The STM task required participants to recognise changes across two consecutive arrays presenting either single features (colour or shape) or feature bindings. The MCI group performed significantly poorer than controls on standard tests of memory, attention and on the binding condition of the STM task, but not on single feature conditions. Performance on the binding task and on standard memory tests did not correlate. Eight MCI patients clearly performed outwith the range of normality in the binding task. However, they did not significantly differ from the other 13 MCI patients in disease severity or demographic and neuropsychological variables. Six patients with binding impairments showed a multiple domain profile whereas ten patients with a preserved binding function showed an amnesic profile [Chi-square = 5.45, p = 0.020]. These results suggest that (1) the binding task is assessing a function different from other memory tests and that (2) STM binding may be differentially impaired in MCI subgroups.

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KW - Alzheimer's

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Fernández-Guinea S, Parra MA, Frank A, Delgado ML, Della Sala S. Short-term memory binding in mild cognitive impairment. 2011. Paper presented at 3rd International Scientific Meeting of the Federation of the European Societies for Neuropsychology, Basel, Switzerland.