Short-term memory binding deficits in Alzheimer's disease

Mario A. Parra, Sharon Abrahams, Katia Fabi, Robert Logie, Simona Luzzi, Sergio Della Sala

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Alzheimer's disease impairs long term memories for related events (e.g. faces with names) more than for single events (e.g. list of faces or names). Whether or not this associative or ‘binding’ deficit is also found in short-term memory has not yet been explored. In two experiments we investigated binding deficits in verbal short-term memory in Alzheimer's disease. Experiment 1 : 23 patients with Alzheimer's disease and 23 age and education matched healthy elderly were recruited. Participants studied visual arrays of objects (six for healthy elderly and four for Alzheimer's disease patients), colours (six for healthy elderly and four for Alzheimer's disease patients), unbound objects and colours (three for healthy elderly and two for Alzheimer's disease patients in each of the two categories), or objects bound with colours (three for healthy elderly and two for Alzheimer's disease patients). They were then asked to recall the items verbally. The memory of patients with Alzheimer's disease for objects bound with colours was significantly worse than for single or unbound features whereas healthy elderly's memory for bound and unbound features did not differ. Experiment 2 : 21 Alzheimer's disease patients and 20 matched healthy elderly were recruited. Memory load was increased for the healthy elderly group to eight items in the conditions assessing memory for single or unbound features and to four items in the condition assessing memory for the binding of these features. For Alzheimer's disease patients the task remained the same. This manipulation permitted the performance to be equated across groups in the conditions assessing memory for single or unbound features. The impairment in Alzheimer's disease patients in recalling bound objects reported in Experiment 1 was replicated. The binding cost was greater than that observed in the healthy elderly group, who did not differ in their performance for bound and unbound features. Alzheimer's disease grossly impairs the mechanisms responsible for holding integrated objects in verbal short-term memory.
LanguageEnglish
Pages1057-1066
Number of pages10
JournalBrain
Volume132
Issue number4
DOIs
Publication statusPublished - 17 Mar 2009

Fingerprint

Memory Disorders
Short-Term Memory
Alzheimer Disease
Color
Names
Long-Term Memory
Education
Costs and Cost Analysis

Keywords

  • memory binding
  • Alzheimer's disease
  • verbal short-term memory

Cite this

Parra, M. A., Abrahams, S., Fabi, K., Logie, R., Luzzi, S., & Della Sala, S. (2009). Short-term memory binding deficits in Alzheimer's disease. Brain, 132(4), 1057-1066. https://doi.org/10.1093/brain/awp036
Parra, Mario A. ; Abrahams, Sharon ; Fabi, Katia ; Logie, Robert ; Luzzi, Simona ; Della Sala, Sergio. / Short-term memory binding deficits in Alzheimer's disease. In: Brain. 2009 ; Vol. 132, No. 4. pp. 1057-1066.
@article{97f99879b1bd4ef59fb80c795bce2865,
title = "Short-term memory binding deficits in Alzheimer's disease",
abstract = "Alzheimer's disease impairs long term memories for related events (e.g. faces with names) more than for single events (e.g. list of faces or names). Whether or not this associative or ‘binding’ deficit is also found in short-term memory has not yet been explored. In two experiments we investigated binding deficits in verbal short-term memory in Alzheimer's disease. Experiment 1 : 23 patients with Alzheimer's disease and 23 age and education matched healthy elderly were recruited. Participants studied visual arrays of objects (six for healthy elderly and four for Alzheimer's disease patients), colours (six for healthy elderly and four for Alzheimer's disease patients), unbound objects and colours (three for healthy elderly and two for Alzheimer's disease patients in each of the two categories), or objects bound with colours (three for healthy elderly and two for Alzheimer's disease patients). They were then asked to recall the items verbally. The memory of patients with Alzheimer's disease for objects bound with colours was significantly worse than for single or unbound features whereas healthy elderly's memory for bound and unbound features did not differ. Experiment 2 : 21 Alzheimer's disease patients and 20 matched healthy elderly were recruited. Memory load was increased for the healthy elderly group to eight items in the conditions assessing memory for single or unbound features and to four items in the condition assessing memory for the binding of these features. For Alzheimer's disease patients the task remained the same. This manipulation permitted the performance to be equated across groups in the conditions assessing memory for single or unbound features. The impairment in Alzheimer's disease patients in recalling bound objects reported in Experiment 1 was replicated. The binding cost was greater than that observed in the healthy elderly group, who did not differ in their performance for bound and unbound features. Alzheimer's disease grossly impairs the mechanisms responsible for holding integrated objects in verbal short-term memory.",
keywords = "memory binding, Alzheimer's disease, verbal short-term memory",
author = "Parra, {Mario A.} and Sharon Abrahams and Katia Fabi and Robert Logie and Simona Luzzi and {Della Sala}, Sergio",
year = "2009",
month = "3",
day = "17",
doi = "10.1093/brain/awp036",
language = "English",
volume = "132",
pages = "1057--1066",
journal = "Brain",
issn = "0006-8950",
number = "4",

}

Parra, MA, Abrahams, S, Fabi, K, Logie, R, Luzzi, S & Della Sala, S 2009, 'Short-term memory binding deficits in Alzheimer's disease' Brain, vol. 132, no. 4, pp. 1057-1066. https://doi.org/10.1093/brain/awp036

Short-term memory binding deficits in Alzheimer's disease. / Parra, Mario A.; Abrahams, Sharon ; Fabi, Katia ; Logie, Robert; Luzzi, Simona ; Della Sala, Sergio.

In: Brain, Vol. 132, No. 4, 17.03.2009, p. 1057-1066.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Short-term memory binding deficits in Alzheimer's disease

AU - Parra, Mario A.

AU - Abrahams, Sharon

AU - Fabi, Katia

AU - Logie, Robert

AU - Luzzi, Simona

AU - Della Sala, Sergio

PY - 2009/3/17

Y1 - 2009/3/17

N2 - Alzheimer's disease impairs long term memories for related events (e.g. faces with names) more than for single events (e.g. list of faces or names). Whether or not this associative or ‘binding’ deficit is also found in short-term memory has not yet been explored. In two experiments we investigated binding deficits in verbal short-term memory in Alzheimer's disease. Experiment 1 : 23 patients with Alzheimer's disease and 23 age and education matched healthy elderly were recruited. Participants studied visual arrays of objects (six for healthy elderly and four for Alzheimer's disease patients), colours (six for healthy elderly and four for Alzheimer's disease patients), unbound objects and colours (three for healthy elderly and two for Alzheimer's disease patients in each of the two categories), or objects bound with colours (three for healthy elderly and two for Alzheimer's disease patients). They were then asked to recall the items verbally. The memory of patients with Alzheimer's disease for objects bound with colours was significantly worse than for single or unbound features whereas healthy elderly's memory for bound and unbound features did not differ. Experiment 2 : 21 Alzheimer's disease patients and 20 matched healthy elderly were recruited. Memory load was increased for the healthy elderly group to eight items in the conditions assessing memory for single or unbound features and to four items in the condition assessing memory for the binding of these features. For Alzheimer's disease patients the task remained the same. This manipulation permitted the performance to be equated across groups in the conditions assessing memory for single or unbound features. The impairment in Alzheimer's disease patients in recalling bound objects reported in Experiment 1 was replicated. The binding cost was greater than that observed in the healthy elderly group, who did not differ in their performance for bound and unbound features. Alzheimer's disease grossly impairs the mechanisms responsible for holding integrated objects in verbal short-term memory.

AB - Alzheimer's disease impairs long term memories for related events (e.g. faces with names) more than for single events (e.g. list of faces or names). Whether or not this associative or ‘binding’ deficit is also found in short-term memory has not yet been explored. In two experiments we investigated binding deficits in verbal short-term memory in Alzheimer's disease. Experiment 1 : 23 patients with Alzheimer's disease and 23 age and education matched healthy elderly were recruited. Participants studied visual arrays of objects (six for healthy elderly and four for Alzheimer's disease patients), colours (six for healthy elderly and four for Alzheimer's disease patients), unbound objects and colours (three for healthy elderly and two for Alzheimer's disease patients in each of the two categories), or objects bound with colours (three for healthy elderly and two for Alzheimer's disease patients). They were then asked to recall the items verbally. The memory of patients with Alzheimer's disease for objects bound with colours was significantly worse than for single or unbound features whereas healthy elderly's memory for bound and unbound features did not differ. Experiment 2 : 21 Alzheimer's disease patients and 20 matched healthy elderly were recruited. Memory load was increased for the healthy elderly group to eight items in the conditions assessing memory for single or unbound features and to four items in the condition assessing memory for the binding of these features. For Alzheimer's disease patients the task remained the same. This manipulation permitted the performance to be equated across groups in the conditions assessing memory for single or unbound features. The impairment in Alzheimer's disease patients in recalling bound objects reported in Experiment 1 was replicated. The binding cost was greater than that observed in the healthy elderly group, who did not differ in their performance for bound and unbound features. Alzheimer's disease grossly impairs the mechanisms responsible for holding integrated objects in verbal short-term memory.

KW - memory binding

KW - Alzheimer's disease

KW - verbal short-term memory

UR - http://www.scopus.com/inward/record.url?scp=65249095311&partnerID=8YFLogxK

U2 - 10.1093/brain/awp036

DO - 10.1093/brain/awp036

M3 - Article

VL - 132

SP - 1057

EP - 1066

JO - Brain

T2 - Brain

JF - Brain

SN - 0006-8950

IS - 4

ER -

Parra MA, Abrahams S, Fabi K, Logie R, Luzzi S, Della Sala S. Short-term memory binding deficits in Alzheimer's disease. Brain. 2009 Mar 17;132(4):1057-1066. https://doi.org/10.1093/brain/awp036